Mapping Microbiomes at the Micron Scale

　　报告题目: Mapping Microbiomes at the Micron Scale

　　报 告 人: Prof. Gary G. Borisy

　　报告人单位: The Forsyth Institute

　　报告时间: 2017年10月18日(星期三)14:30 pm ~ 15:30 pm

　　报告地点: A102会议室

　　主 持 人: 刘双江 研究员

　　报告摘要:

　　The physiology and ecology of complex microbial communities are strongly dependent on the immediate surroundings of each microbe, including the identity of neighboring microbes; however, information on the micron-scale organization of microbiomes is largely lacking. Using sequencing data combined with spectral fluorescence imaging, we have discovered multi genus highly organized microbial consortium in human oral and gut microbiomes. The spatial structure of the consortium reveals unanticipated interactions and provides a framework for understanding the organization, metabolism, and systems biology of the microbiome and ultimately, its effect on the health of the human host. Our synthesis of high-throughput sequencing data with spatial and structural information shows the informative value of microbial biogeography at the micron scale.

　　Background reading:

　　(1) Welch J L M, Rossetti B J, Rieken C W, et al. Biogeography of a human oral microbiome at the micron scale[J]. Proceedings of the National Academy of Sciences, 2016, 113(6): E791-E800.

　　(2) Welch J L M, Hasegawa Y, McNulty N P, et al. Spatial organization of a model 15-member human gut microbiota established in gnotobiotic mice [J]. Proceedings of the National Academy of Sciences, 2017, doi: 10.1073/pnas.1711596114

　　报告人简介：

　　Prof. Gary G. Borisy

　　Senior Research Investigator at The Forsyth Institute

　　Education

　　1962 University of Chicago B.S., Biochemistry

　　1966 University of Chicago Ph.D., Biophysics

　　1966-68 Medical Research Council Postdoctoral Fellow

　　Professional Experience:

　　Gary Borisy is currently a Senior Investigator at The Forsyth Institute, coming to this position after serving as President and Director of the Marine Biology Laboratory in Woods Hole, MA. Dr. Borisy received his Ph.D in Biophysics from the University of Chicago and carried out postdoctoral studies at the Medical Research Council Laboratory of Molecular Biology in Cambridge, England. He was Perlman-Bascom Professor and Chair of Molecular Biology at the University of Wisconsin, Madison, then Arey Professor of Cell and Molecular Biology at Northwestern University in Chicago where he also served as Associate Vice President for Research. He is a recipient of numerous awards including an NIH MERIT Award, the Carl Zeiss Award from the German Society for Cell Biology, the Distinguished Alumni Award from the University of Chicago and the E.B. Wilson Award from the American Society of Cell Biology. Dr. Borisy is a past President of the American Society for Cell Biology, a Fellow of the American Association for the Advancement of Science, an elected member of the American Academy of Arts and Sciences and an elected member of the U.S. National Academy of Sciences. He has authored or co-authored 240 publications with more than 34,000 total citations.

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