孙蕾 博士 项目研究员 |
研究方向 病毒感染与免疫及抗病毒/抗炎症药物研究
研究内容
流感病毒的感染与复制机制、病毒感染诱发宿主免疫应答的调控机制、抗病毒/抗炎症制剂研究。
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导师简介
导师姓名:孙蕾 电话:010-64807503 电子邮件:sunlei362#im.ac.cn(请将#换为@) 通讯地址:北京市朝阳区北辰西路1号院3号 邮政编码:100101
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主要学习及工作经历
工作经历 2019.10– 至今 中国科学院微生物研究所,项目研究员 2011.08–2012.11 美国康奈尔大学威尔康奈尔医学院,访问助理教授 2009.06–2019.10 中国科学院微生物研究所,副研究员 2005.07–2009.06 中国科学院微生物研究所,助理研究员
学习经历 2000.09–2005.06 扬州大学预防兽医学专业,博士学位 1996.09–2000.09 山东农业大学兽医专业,学士学位
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近年代表性研究论文(*通讯作者)
1. Wenxian Yang, Xiaoyuan Bai, Xiaohan Luan, Jie Min, Xiaodong Tian, Heqiao Li, Huizi Li, Wenqiang Sun, Wei Liu, Wenhui Fan, Wenjun Liu*,Lei Sun*. Delicate regulation of IL-1β-mediated inflammation by cyclophilin A.Cell Reports, 2022, 38(11):110513. 2. Xiaoyuan Bai, Wenxian Yang, Heqiao Li, Yuna Zhao, Wenhui Fan, He Zhang, Wenjun Liu,Lei Sun*. Cyclosporin A regulates influenza A virus-induced macrophages polarization and inflammatory responses by targeting cyclophilin A.Frontiers in Immunology, 2022,13:861292 3. Wenxian Yang, Xiaoyuan Bai, Heqiao Li, Huizi Li, Wenhui Fan, He Zhang, Wenjun Liu,Lei Sun*. Influenza A and B virus-triggered epithelial–mesenchymal transition is relevant to the binding ability of NA to latent TGF-β.Frontiers in Microbiology, 2022, 13:841462. 4. Xiaoyuan Bai, Wenxian Yang, Xiaohan Luan, Huizi Li, Heqiao Li, Deyu Tian, Wenhui Fan, Jing Li, Beinan Wang, Wenjun Liu*,Lei Sun*. Induction of cyclophilin A by influenza A virus infection facilitates group AStreptococcuscoinfection.Cell Reports, 2021, 35, 109159. 5. Xiaohan Luan#, Wenxian Yang#, Xiaoyuan bai, Heqiao Li, Huizi Li, Wenhui Fan, He Zhang, Wenjun Liu,Lei Sun*. Cyclophilin A is a key positive and negative feedback regulator within interleukin-6 trans-signaling pathway.FASEB Journal, 2021, 35:e21958. 6. Weinan Zheng#, Liang Cui#, Minghui Li#, Yun Li, Wenhui Fan, Limin Yang, Jing Li,Lei Sun*, Wenjun Liu. Nucleoprotein Y385 dephosphorylation confers the cold sensitivity to influenza A virus through impairing nucleoprotein oligomerization at a low temperature.Science China-Life Sciences, 2021, 64(4):633-643. 7. Weinan Zheng, Wenhui Fan, Shuang Zhang, Pengtao Jiao, Yingli Shang, Liang Cui, Madina · Mahesutihan, Jing Li, Dayan Wang, George Fu Gao,Lei Sun*, Wenjun Liu. Naproxen exhibits broad anti-influenza virus activity in mice by impeding viral nucleoprotein nuclear export.Cell Reports, 2019, 27:1875–1885. 8. Liang Cui#, Weinan Zheng#, Minghui Li#, Xiaoyuan Bai, Wenxian Yang, Jing Li, Wenhui Fan, George Fu Gao,Lei Sun*, Wenjun Liu. Phosphorylation Status of Tyrosine 78 Residue Regulates the Nuclear Export and Ubiquitination of Influenza A Virus Nucleoprotein.Frontiers in Microbiology, 2019, 10:1816. 9. Can Chen, Wenhui Fan, Jing Li, Weinan Zheng, Shuang Zhang, Limin Yang, Di Liu, Wenjun Liu*,Lei Sun*. A promising IFN-Deficient system to manufacture IFN-Sensitive influenza vaccine virus.Frontiers in Cellular and Infection Microbiology, 2018, 8:127. 10. Wei Liu#, Jing Li#, Weinan Zheng, Yingli Shang, Zhendong Zhao, Shanshan Wang, Yuhai Bi, Shuang Zhang, Chongfeng Xu, Ziyuan Duan, Lianfeng Zhang, Yue L. Wang, Zhengfan Jiang, Wenjun Liu*,Lei Sun*. Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses.eLife,2017, 6:e24425.(获F1000推荐和点评)
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