T细胞免疫与疫苗免疫研究组

组长:朱明昭  博士、研究员

 

 研究队伍


 研究组长:朱明昭 研究员 博士生导师

 电子邮件:zhumz#im.ac.cn(#替换成@)

 通讯地址:北京市朝阳区北辰西路1号院3号

 邮编:100101

 

 

  研究方向


T细胞的发育、稳态、应答和记忆

1.  淋巴组织微环境调控T细胞免疫的作用和机制

2.  表观遗传调控T细胞免疫的作用和机制

3.  疫苗免疫学

 

 

  研究内容及意义


利用疫苗、感染和肿瘤等动物模型,结合临床样本,从淋巴组织微环境(外因)和表观遗传(内因)两个角度,系统研究T细胞发育、稳态、应答和记忆等重要免疫事件的细胞和分子调控机制,揭示其生理病理意义,研发创新型疫苗和免疫干预新策略。

              

 

  主要学习及工作经历

 

 1994.09 – 1998.07  北京大学 生命科学学院 生物技术系,学士

 1998.09 – 2003.07  中国医学科学院 基础医学研究所,博士

 2004.01 – 2008.12  芝加哥大学 病理系,博士后

 2009.01 – 2009.12  芝加哥大学 病理系,研究助理教授

 2009.10 – 2023.11  中国科学院 生物物理研究所,研究员

 2015.10至今   中国科学院大学 生命科学学院,岗位教授

 2023.11至今   中国科学院 微生物研究所,研究员

 

 

  获奖情况


2020年  国家自然科学基金委杰出青年科学基金(医学免疫学)

 2020  中国科学院大学朱李月华优秀教师奖

 2021  药明康德生命化学研究奖学者奖

 2021   2020年度中国科学十大进展

 2022  中国科学院杰出科技成就奖(集体奖)

 

 工作人员

柴谦 副研究员
王文君 副研究员
吕梦捷 助理研究员


     研究生

详见:https://people.ucas.edu.cn/-zhumz

 

  代表性论文

 

1.Ren, B., Xia, H., Liao, Y., Zhou, H., Wang, Z., Shi, Y., andZhu, M.*(2022) Endothelial SIRP signaling controls thymic progenitor homing for T cell regeneration and antitumor immunity.Elife11:e69219

2. Zhu, M*. (2021) Immunological perspectives on spatial and temporal vaccine delivery.Advanced Drug Delivery Reviews178, 113966

3. Duan, H., Jing, L., Jiang, X., Ma, Y., Wang, D., Xiang, J., Chen, X., Wu, Z., Yan, H., Jia, J., Liu, Z., Feng, J.,Zhu, M.*, and Yan, X.* (2021) CD146 bound to LCK promotes TCR signaling and anti-tumor immune response in mice.J Clin Invest131, 148568

4. Xia, H., Zhong, S., Zhao, Y., Ren, B., Wang, Z., Shi, Y., Chai, Q., Wang, X.*, andZhu, M.*(2021) Thymic Egress Is Regulated by T Cell-Derived LT R Signal and via Distinct Thymic Portal Endothelial Cells.Frontiers in Immunology12, 707404

5. Wang, W., Huang, B., Zhu, Y., Tan, W.*, andZhu, M.*(2021) Ferritin nanoparticle-based SARS-CoV-2 RBD vaccine induces a persistent antibody response and long-term memory in mice.Cellular & Molecular Immunology18, 749-751

6. Wang, W., Zhou, X., Bian, Y., Wang, S., Chai, Q., Guo, Z., Wang, Z., Zhu, P., Peng, H., Yan, X., Li, W., Fu, Y.-X., andZhu, M.*(2020) Dual-targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic hepatitis B.Nature Nanotechnology15, 406-416

7. Long, H., Zhang, L., Lv, M., Wen, Z., Zhang, W., Chen, X., Zhang, P., Li, T., Chang, L., Jin, C., Wu, G., Wang, X., Yang, F., Pei, J., Chen, P., Margueron, R., Deng, H.,Zhu, M.*, and Li, G.* (2020) H2A.Z facilitates licensing and activation of early replication origins.Nature577, 576-581

8. Pian, Y., Chai, Q.*, Ren, B., Wang, Y., Lv, M., Qiu, J., andZhu, M.*(2020) Type 3 Innate Lymphoid Cells Direct Goblet Cell Differentiation via the LT-LT R Pathway during Listeria Infection.J Immunol205, 853-863

9. Wang, Z., Wang, W., Chai, Q., andZhu, M.*(2019) Langerhans Cells Control Lymphatic Vessel Function during Inflammation via LIGHT-LT R Signaling.J Immunol202, 2999-3007

10. Wang, W., Liu, Z., Zhou, X., Guo, Z., Zhang, J., Zhu, P., Yao, S., andZhu, M.* (2019) Ferritin nanoparticle-based SpyTag/SpyCatcher-enabled click vaccine for tumor immunotherapy.Nanomedicine: nanotechnology, biology, and medicine16, 69-78

11. Wang, Z., Chai, Q.*, and Zhu, M.* (2018) Differential Roles of LTbetaR in Endothelial Cell Subsets for Lymph Node Organogenesis and Maturation.J Immunol201, 69-76

12. Liu, X., Liu, L., Ren, Z., Yang, K., Xu, H., Luan, Y., Fu, K., Guo, J., Peng, H.,Zhu, M.*, and Fu, Y. X.* (2018) Dual Targeting of Innate and Adaptive Checkpoints on Tumor Cells Limits Immune Evasion.Cell Rep24, 2101-2111

13. Jin, C., andZhu, M.*(2018) RelB intrinsically regulates the development and function of medullary thymic epithelial cells.Sci China Life Sci61, 1039-1048.

14. Jin, L., Guo, X., Shen, C., Hao, X., Sun, P., Li, P., Xu, T., Hu, C., Rose, O., Zhou, H., Yang, M., Qin, C.-F., Guo, J., Peng, H.,Zhu, M., Cheng, G., Qi, X., and Lai, R. (2018) Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin- receptor.Nature Immunology19, 342-353

15. Yang, K., Liang, Y., Sun, Z., Xue, D., Xu, H.,Zhu, M., Fu, Y. X., and Peng, H. (2018) T Cell-Derived Lymphotoxin Is Essential for the Anti-Herpes Simplex Virus 1 Humoral Immune Response.J Virol92, e00428-00418

16. Wu, W., Shi, Y., Xia, H., Chai, Q., Jin, C., Ren, B., andZhu, M.*(2017) Epithelial LTbetaR signaling controls the population size of the progenitors of medullary thymic epithelial cells in neonatal mice.Scientific Reports7, 44481

17. Liu, Z., Zhou, C., Qin, Y., Wang, Z., Wang, L., Wei, X., Zhou, Y., Li, Q., Zhou, H., Wang, W., Fu, Y.-X.*,Zhu, M.*, and Liang, W.* (2017) Coordinating antigen cytosolic delivery and danger signaling to program potent cross-priming by micelle-based nanovaccine.Cell Discovery3, 17007

18. Wang, J., Ge, P., Qiang, L., Tian, F., Zhao, D., Chai, Q.,Zhu, M., Zhou, R., Meng, G., Iwakura, Y., Gao, G. F., and Liu, C. H. (2017) The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation.Nature Communications8, 244

19. Shi, Y., Wu, W., Chai, Q., Li, Q., Hou, Y., Xia, H., Ren, B., Xu, H., Guo, X., Jin, C., Lv, M., Wang, Z., Fu, Y. X., andZhu, M.*(2016) LTbetaR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration.Nature Communications7, 12369

20. Tang, H.,Zhu, M., Qiao, J., and Fu, Y. X. (2017) Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy. Cell Mol Immunol 14(10):809-818

21. Liu, Z., Zhou, H., Wang, W., Fu, Y. X., andZhu, M.*(2016) A novel dendritic cell targeting HPV16 E7 synthetic vaccine in combination with PD-L1 blockade elicits therapeutic antitumor immunity in mice.Oncoimmunology5, e1147641

22. Lv,M., Wu, W., Zhang, Y., andZhu, M.*(2015) Herpes virus entry mediator licenses Listeria infection induced immunopathology through control of type I interferon.Scientific Reports5, 12954

23. Liu, Z., Zhou, H., Wang, W., Tan, W., Fu, Y. X., andZhu, M.*(2014) A novel method for synthetic vaccine construction based on protein assembly.Scientific Reports4, 7266

24. Shi, Y., andZhu, M.*(2013) Medullary thymic epithelial cells, the indispensable player in central tolerance.Sci China Life Sci56, 392-398

25. Hou, Y., Lin, H., Zhu, L., Liu, Z., Hu, F., Shi, J., Yang, T., Shi, X.,Zhu, M., Godley, B. F., Wang, Q., Li, Z., and Zhao, Y. (2013) Lipopolysaccharide increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA-1 expression.Arthritis and Rheumatism65, 2835-2846

26. Zhu, M.*, and Fu, Y.* (2012) Proinflammatory IL-17 induces iBALT development.Cell Mol Immunol9, 101-102

27. Zhu, M.*, Yang, Y., Wang, Y., Wang, Z., and Fu, Y.-X.* (2011) LIGHT Regulates Inflamed Draining Lymph Node Hypertrophy.J Immunol186, 7156-7163

28. Zhu, M., and Fu, Y.-X. (2011) The role of core TNF/LIGHT family members in lymph node homeostasis and remodeling.Immunological Reviews244, 75-84

29. Zhu, M.*, and Fu, Y.-X.* (2011) Deflating the Lymph Node.Immunity34, 8-10

30. Zhu, M.*, and Fu, Y.* (2010) The complicated role of NF-kappaB in T-cell selection.Cell Mol Immunol7, 89-93

31. Zhu, M.*, Brown, N. K., and Fu, Y.-X.* (2010) Direct and indirect roles of the LT[beta]R pathway in central tolerance induction.Trends in Immunology31, 325-331

32. Wang, Y.,Zhu, M., Yu, P., and Fu, Y. X. (2010) Promoting immune responses by LIGHT in the face of abundant regulatory T cell inhibition.J Immunol184, 1589-1595

33. Zhou, P., Fang, X., McNally, B. A., Yu, P.,Zhu, M., Fu, Y. X., Wang, L., Liu, Y., and Zheng, P. (2009) Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition.Proc Natl Acad Sci U S A106, 17134-17139

34. Wang, Y.,Zhu, M., Miller, M., and Fu, Y. X. (2009) Immunoregulation by tumor necrosis factor superfamily member LIGHT.Immunol Rev229, 232-243

35. Zhu, M., and Fu, Y. X. (2008) Coordinating development of medullary thymic epithelial cells.Immunity29, 386-388

36. Zhu, M., Chin, R. K., Tumanov, A. V., Liu, X., and Fu, Y. X. (2007) Lymphotoxin beta receptor is required for the migration and selection of autoreactive T cells in thymic medulla.J Immunol179, 8069-8075

37. Li, J., Li, Y., Yao, J. Y., Jin, R.,Zhu, M. Z., Qian, X. P., Zhang, J., Fu, Y. X., Wu, L., Zhang, Y., and Chen, W. F. (2007) Developmental pathway of CD4+CD8- medullary thymocytes during mouse ontogeny and its defect in Aire-/- mice.Proc Natl Acad Sci U S A104, 18175-18180

38. Zhu, M., Chin, R. K., Christiansen, P. A., Lo, J. C., Liu, X., Ware, C., Siebenlist, U., and Fu, Y. X. (2006) NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathway.J Clin Invest116, 2964-2971

39. Chin, R. K.,Zhu, M., Christiansen, P. A., Liu, W., Ware, C., Peltonen, L., Zhang, X., Guo, L., Han, S., Zheng, B., and Fu, Y. X. (2006) Lymphotoxin pathway-directed, autoimmune regulator-independent central tolerance to arthritogenic collagen.J Immunol177, 290-297

40. Zhu, M., Xu, X., Liu, H., Liu, X., Wang, S., Dong, F., Yang, B., and Song, G. (2003) Enhancement of DNA vaccine potency against herpes simplex virus 1 by co-administration of an interleukin-18 expression plasmid as a genetic adjuvant.J Med Microbiol52, 223-228