微生物药物研究组

研究队伍 

课题组长：张立新　博士 研究员　

中国科学院病原微生物与免疫学重点实验室副主任 结核药物研发中心主任

电话：010-64807665

传真：010-64806058

电子邮件：lzhang03@gmail.com 

通讯地址：北京市朝阳区北辰西路1号院3号F815中国科学院微生物研究所

邮编：100101 

1 

专著：Zhang, L.*, andA. Demain.(Editors-in-Chief) 2005. " Natural Products: Drug Discovery, Therapeutic Medicine ", ISBN: 1-58829-383-1,Humana Press, USA  

2  

Wupeng Yan, Heng Song, Fuhang Song, Yisong Guo, Cheng-Hsuan Wu, Ampon Sae Her, Yi Pu, Shu Wang, Nathchar Naowarojna, Andrew Weitz, Michael P. Hendrich, Catherine E. Costello, Zhang L*, Pinghua Liu*, and Yan Jessie Zhang*. 2015. Endoperoxide Formation Catalyzed by FtmOx1, an α-Ketoglutarate-dependent Mononuclear Non-heme Iron Enzyme. Nature, 527, 539–543  

3  

Bai C, Zhang Y, Zhao X, Hu Y, Xiang S, Miao J, Lou C*, Zhang L*. 2015. Exploiting a precise design of universal synthetic modular regulatory elements to unlock the microbial natural products in Streptomyces. Proc Natl Acad Sci U S A. 112 (39), 12181-6  

4  

Wang Qian^＃, Song Fuhang^＃, Xiao Xue^＃, Huang Pei, Li Li, Aaron Monte, Wael M. Abdel-Mageed, Wang Jian, Guo Hui, He Wenni, Xie Feng, Dai Huanqin, Liu Miaomiao, Chen Caixia, Xu Hao, Liu Mei, Andrew M. Piggott, Liu Xueting*, Robert J. Capon*,Zhang Lixin*. 2013. Abyssomicins from a South China Sea deep-sea sediment Verrucosispora sp.: Natural thioether Michael addition adducts as potential antitubercular prodrugs. Angew. Chem.-Int. Edit. 52, 1231-1234.  

5  

Ashforth Elizabeth Jane, Fu Chengzhang, Liu Xiangyang, Dai Huanqin, Song Fuhang, Guo Hui,Zhang Lixin*. 2010. Bioprospecting for antituberculosis leads from microbial metabolites.Nat Prod Rep.27: 1709-1719.  

6  

Ying Zhuo, Wenquan Zhang, Difei Chen, Hong Gao, Jun Tao, Mei Liu, Zhongxuan Gou, Xianlong Zhou, Bangce Ye, Qing Zhang, Siliang Zhang, andL Zhang*. 2010. Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis.Proc Natl Acad Sci USA.107: 11250-4  

7  

Zhang, L*., Yan K, Zhang Y, Bian J, Zheng C, Sun H, Chen Z, Sun N, Song Y, Zhuo Y, You J, et al. 2007. High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections.Proc. Natl. Acad. Sci.USA.104(11): 4606-11   

8  

Zhang HM^＃, Dai H^＃, Hanson PJ, Li H, Guo H, Ye X, Hemida MG, Wang L, Tong Y, Qiu Y, Liu S, Wang F, Song F, Zhang B, Wang JG,Zhang L*, Yang D*. 2014.Antiviral Activity of an Isatin Derivative via Induction of PERK-Nrf2-mediated suppression of Cap-independent Translation.ACS Chem Biol.9(4), 1015–1024  

9  

Wang F, Wang Y, Ji J, Zhou Z, Yu J, Zhu H, Su Z,Zhang L*, Zheng J. 2015. Structural and Functional Analysis of the Loading Acyltransferase from Avermectin Modular Polyketide Synthase.ACS Chem Biol.10(4),1017–1025  

10  

Zhang, L*., An, R.; Wang, J.; Sun, N.; Zhang, S.; Hu, J.; Kuai, J. 2005. Exploring novel bioactive compounds from marine microbes.Current Opinion In Microbiology, 8(3): 276-281  

11  

SONG Fuhang^＃, LIU Xinru^＃, GUO Hui, REN Biao, CHEN Caixia, Andrew M. Piggott, YU Ke, GAO Hong, WANG Qian, LIU Mei, DAI Huanqin,ZHANG Lixin*and Robert J. Capon. 2012. Brevianamides with antitubercular potential from a marine-derived isolate of Aspergillus versicolor.Organic Letters,14(18), 4770–4773  

12  

Zhang Jingyu, Abdel-mageed Wael M., Liu Miaomiao, Huang Pei, He Wenni, Li Li, Song Fuhang, Dai Huanqin, Liu Xueting*, Jingyu Liang*,Zhang Lixin*. 2013. Caesanines A-D, new cassane diterpenes with unprecedented N bridge from Caesalpinia sappan. Organic Letters. 15(18), 4726-4729.   

13  

Chen Caixia, Liu Xueting, Abdel-Mageed Wael M, Guo Hui, Hou Weiyuan, Jaspars Marcel, Li Li, Xie Feng, Ren Biao, Wang Qian, Dai Huanqin, Song Fuhang*,Zhang Lixin*.2013. Nivetetracyclates A and B: novel compounds isolated from Streptomyces niveus. Organic Letters. 15(22), 5762–5765