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叶健研究组

虫媒病毒与宿主互作 研究组

组长:叶健 博士 研究员

研究方向
1. 虫媒病毒—植物—介体昆虫互作的分子机理;2. 植物油脂代谢产物在抗病免疫中的作用


研究内容及意义

1. 全球气候变暖,极端天气频发,入侵型、新发和重发昆虫传作物病毒病害已经成为限制我国农作物优质高产的主要因素。因缺乏抗病抗虫的种质资源、育种周期长,虫传病害防治难度极大,目前处于几乎完全依赖化学防控媒介昆虫的被动应付局面,生态与环境成本极大。以往研究虫传病毒病害往往注重病毒和植物寄主两个方面,这些研究为理解作物病毒病害的爆发机制提供了基础知识,但对于病害防控的关键节点—媒介昆虫介导的病毒侵染循环这一根本性问题上尚较缺乏,导致目前在病毒病害防治实践上缺乏有效抓手。近年来,随着分子生物学和组学研究的飞速发展,本课题组致力于将微观生物学技术和理念,整合宏观生物学的现象和规律,寻找病毒病害流行爆发的宏观生态学现象背后的分子生物学与生物化学机制,努力建立复杂生态系统多元互作分子机制提供数学模型,并利用自然规律设计人工干扰和操纵生物间互作关键节点,变被动应付为主动调控病害灾变过程。具体研究成果参见近期代表工作1和近期代表工作2

2. 植物脂肪酸和油脂代谢相关遗传因子在植物免疫识别和信号传导过程中发挥了重要作用,我们的研究将着重于植物免疫相关代谢物的发掘和功能鉴定,并应用于作物的分子品种设计,培育优质、高产新品种。(参见近期代表工作3

研究组长

叶健 博士、研究员、国家优秀青年科学基金获得者(2015

电话:64807363O);64806195L
电子邮件:jianye#im.ac.cn(请将#换成@
通讯地址:北京市朝阳区北辰西路1号院3号中科院微生物所
邮政编码:100101


学习经历
2000–2007,中国科学院微生物研究所,博士
1996–2000,浙江大学农业与生物技术学院,学士


工作经历
2014–至今,中科院微生物所,青年课题组长
2013–2014,新加坡国立大学淡马锡生命科学研究院,Principal Investigator
2011–2013,新加坡国立大学淡马锡生命科学研究院,Biotechnology Manager
2009–2010,新加坡国立大学淡马锡生命科学研究院,Research Fellow
2007–2009,新加坡国立大学淡马锡生命科学研究院,博士后


获奖
浙江大学 竺可桢奖学金

研究队伍(请将#换成@

工作人员
孙艳伟 女 助理研究员 
sunyw#im.ac.cn
姚香梅 女 助理研究员 yaoxm#im.ac.cn

在站博士后
赵平芝 女 zhao83412#163.com

在读研究生
类别 姓名 性别 邮箱
硕士生 马永焕 女 18766177310#163.com
硕士生 龚雨晴 女
gongyuqing15#mails.ucas.ac.cn
硕士生 徐 爽 男 979138774#qq.com

客座研究生
博士生 王 宁 女 山东农业大学 wangning0847#163.com

实习生
吴晓娟(山东农业大学),王端(河北大学)


著书章节(*通讯作者, #共同第一作者)

  1. Ma YH, Ye J*. 2017. Lipid biosynthesis and regulation in Jatropha curcas, an emerging model for woody energy plants. The Jatropha Genome. Compendium of Plant Genomes. Suguru Tsuchimoto (Ed.) Jatropha. Springer Science Publishers, New York.

  2. Ye J, Wang CM, Yue GH. 2017. Jatropha breeding. The Jatropha Genome. Compendium of Plant Genomes. Suguru Tsuchimoto (Ed.) Jatropha. Springer Science Publishers, New York.

  3. Ye J*, Hong Y, Qu J, Wang CM. 2012. Improvement of Jatropha oil by genetic transformation. Jatropha, Challenges for a New Energy Crop-Genetic Improvement and Biotechnology, vol. 2. Springer Science Publishers, New York.

  4. Qu J, Ye J, Fang RX. 2012. Artificial MicroRNAs for Plant Virus Resistance, Antiviral Resistance in Plants: Methods and Protocols, Methods in Molecular Biology, vol. 894


发表论文(*通讯作者, #共同第一作者)

2017

  1. 叶 健*,龚雨晴,方荣祥*,病毒—媒介昆虫—植物三者互作研究进展及展望. 中国科学院院刊.已接收

  2. Sun YW#, Wang CM#, Wang N#, Jiang XY, Mao HZ, Zhu CX, Wen FJ, Wang XH, Lu ZJ, Yue GH, Xu ZF, Ye J*. 2017. Manipulation of Auxin Response Factor 19 affects seed size in the woody perennial Jatropha curcas. Scientific reports. 7: 40844.

  3. Jin JJ, Sun YW#, Qu J, Rahmadsyah, Lim CH, Alfiko Y, NurEstyaBte Rahman, Suwanto A, Yue GH, Wong LS, Chua NH, Ye J*. 2017. Transcriptome and functional analysis reveals hybrid vigor for oil biosynthesis in oil palm. Scientific reports. 7: 439.



2016

  1. Jun Liu#, Shulin Deng#, HW Wu#, Ye J, Hui-Wen Wu, Hai-Xi Sun, and Nam-Hai Chua. 2016. CURLY LEAF Regulates Gene Sets Coordinating Seed Size and Lipid Biosynthesis in Arabidopsis. Plant physiology. 17 (1) 424-436.

  2. Tang W#, Wu T#, Ye J, Sun J, Jiang Y, Yu J, Tang J, Chen G, Wang C, Wan J. 2016. SNP-based analysis of genetic diversity reveals important alleles associated with seed size in rice. BMC Plant Biology 16:93.

  3. Wang N#, Yao YM#, Zhu CX, Wen FJ*, Ye J*. 2016 Towards sustainable protection against insect-borne plant viral diseases: phytohormones and beyond. Science Foundation in China. 24(2). Review. Cover

  4. Pingzhi Zhao, Lubomir N. Sokolov, Ye Jian, Cheng-Yi Tang, Jisen Shi, Yan Zhen, Wenzhi Lan, Zhi Hong, Jinliang Qi, Gui-Hua Lu, Girdhar K. Pandey & Yong-Hua Yang. 2016 The LIKE SEX FOUR2 regulates root development by modulating reactive oxygen species homeostasis in Arabidopsis. Scientific reports. srep28683.

  5. Jin JJ#, Lee M#, Bai B#, Sun Yanwei#, Qu J, Rahmadsyah, Yuzer A, Lim CH, Suwanto A, Sugiharti M, Wong LS, Ye Jian*, Chua NH* and Yue GH*. 2016 Draft genome sequence of an elite Dura palm and whole-genome patterns of DNA variation in oil palm. DNA Research. 23:527.

  6. 龚雨晴,姚香梅,徐爽,孙艳伟,王宁,马永焕,赵平芝,应晓宝,叶健*. 微生物组学研究与经济作物虫传病害的绿色防控. 《植物保护与农产品安全》 201612



2015

  1. Ye J*, Yang J, Sun Y, Zhao P, Gao S, Jung C, Qu J, Fang R, Chua NH*. 2015. Geminivirus Activates ASYMMETRIC LEAVES 2 to Accelerate Cytoplasmic DCP2-Mediated mRNA Turnover and Weakens RNA Silencing in Arabidopsis. PLoS pathogens 11:e1005196.

  2. Sun YW#, Tee CS#, Ma YH#, Wang G, Yao XM, Ye J*. 2015. Attenuation of Histone Methyltransferase KRYPTONITE-mediated transcriptional gene silencing by Geminivirus. Scientific reports 5:16476.

  3. Li R, Tee C, Jiang Y, Jiang X, Venkatesh P, Sarojam R, Ye J*. 2015. A terpenoid phytoalexin plays a role in basal defense of Nicotiana benthamiana against Potato virus X. Scientific reports 5:9682.

  4. Wang H NQ, Wu HW, Liu J, Ye J, Yu N, Chua NH. 2015. Analysis of noncoding transcriptome in rice and maize uncovers roles of conserved lncRNAs associated with agriculture traits. The Plant Journal 84 2: 404-416.

  5. Lee M, Xia J, Zou Z, Ye J, Rahmadsyah, Alfiko Y, Jin J, Lieando J, Purnamasari M, Lim C, Suwanto A, Wong L, Chua N, Yue G. 2015. A consensus linkage map of oil palm and a major QTL for stem height. Scientific reports 5:8232.



2014

  1. Li R, Weldegergis BT, Li J, Jung C, Qu J, Sun Y, Qian H, Tee C, van Loon JJ, Dicke M, Chua NH, Liu SS, Ye J*. 2014. Virulence factors of geminivirus interact with MYC2 to subvert plant resistance and promote vector performance. The Plant cell 26:4991-5008.

  2. Ye J, Qu J, Mao HZ, Ma ZG, Rahman NE, Bai C, Chen W, Jiang SY, Ramachandran S, Chua NH. 2014. Engineering geminivirus resistance in Jatropha curcus. Biotechnology for biofuels 7:149.

  3. Ye J, Geng Y, Zhang B, Mao H, Qu J, Chua N. 2014. The Jatropha FT ortholog is a systemic signal regulating growth and flowering time. Biotechnology for biofuels 7:19.

  4. Ye J, Liu P, Zhu C, Qu J, Wang X, Sun Y, Sun F, Jiang Y, Yue G, Wang C. 2014. Identification of candidate genes JcARF19 and JcIAA9 associated with seed size traits in Jatropha. Functional & integrative genomics 14:757-766.

  5. Wang G, Sun Y, Xu R, Qu J, Tee C, Jiang X, Ye J*. 2014. DNA-A of a highly pathogenic Indian cassava mosaic virus isolated from Jatropha curcas causes symptoms in Nicotiana benthamiana. Virus genes 48:402-405.



2013年及以前

  1. Wang C, Ye J, Tang W, Liu Z, Zhu C, Wang M, Wan J. 2013. Loop nucleotide polymorphism in a putative miRNA precursor associated with seed length in rice (Oryza sativa L.). International journal of biological sciences 9:578-586.

  2. Wang CM, Liu P, Sun F, Li L, Liu P, Ye J, Yue GH. 2012. Isolation and identification of miRNAs in Jatropha curcas. International journal of biological sciences 8:418-429.

  3. Qu J, Ye J#, Geng YF, Sun YW, Gao SQ, Zhang BP, Chen W, Chua NH. 2012. Dissecting functions of KATANIN and WRINKLED1 in cotton fiber development by virus-induced gene silencing. Plant physiology 160:738-748.

  4. Ye J*, Hong Y, Qu J, Wang C. 2012. Improvement of Jatropha oil by genetic transformation. Jatropha, Challenges for a New Energy Crop- Genetic Improvement and Biotechnology, vol. 2. Springer Science Publishers, New York.

  5. Qu J, Mao HZ, Chen W, Gao SQ, Bai YN, Sun YW, Geng YF, Ye J*. 2012. Development of marker-free transgenic Jatropha plants with increased levels of seed oleic acid. Biotechnology for biofuels 5:10.

  6. Qu J, Ye J, Fang R. 2012. Artificial MicroRNAs for Plant Virus Resistance, Antiviral Resistance in Plants: Methods and Protocols, Methods in Molecular Biology, vol. 894.

  7. Sun F, Liu P, Ye J, Lo LC, Cao S, Li L, Yue GH, Wang CM. 2012. An approach for jatropha improvement using pleiotropic QTLs regulating plant growth and seed yield. Biotechnology for biofuels 5:42.

  8. Gao S, Qu J, Chua NH, Ye J*. 2010. A new strain of Indian cassava mosaic virus causes a mosaic disease in the biodiesel crop Jatropha curcas. Archives of virology 155:607-612.

  9. Ye J, Qu J, Zhang JF, Geng YF, Fang RX. 2009. A critical domain of the Cucumber mosaic virus 2b protein for RNA silencing suppressor activity. FEBS letters 583:101-106.

  10. Ye J, Qu J, Bui HT, Chua NH. 2009. Rapid analysis of Jatropha curcas gene functions by virus-induced gene silencing. Plant biotechnology journal 7:964-976.

  11. Qu J, Ye J#, Fang R. 2007. Artificial microRNA-mediated virus resistance in plants. Journal of virology 81:6690-6699.

  12. Xu Y, Ye J#, Liu H, Cheng E, Yang Y, Wang W, Zhao M, Zhou D, Liu D, Fang R. 2008. DNA-templated CMV viral capsid proteins assemble into nanotubes. Chemical Communications 1:49-51.

  13. Ye J, Liu L, Xue Y, Qu J, Gao G, Fang R. 2007. Efficient depletion of multiple SARS-CoV mRNAs by a single small interfering RNA targeting the leader sequence. Progress in Biochemistry and Biophysics 34:1092-1100.


国际专利

  1. Jian Ye, et al. Transcriptome and functional analysis reveals a single gene hybrid vigor for oil yield in oil palm. (US Provisional Patent Application No. 62/082,341)

  2. Jian Ye et al.. A method to enhance plant virus resistance. (United States patent, PCT/SG2014/00003)

  3. Jian Ye et al. Control of pests in plants. (U.S. Patent Application US 2012/02400288A1).

  4. Jian Ye et al. Virus induced gene silencing (VIGS) for functional analysis of genes in cotton. (United States Patent 20120096595).

  5. Jian Ye et al. Functional analysis of Jatropha curcas genes. (United States Patent 20110265233).

  6. Jian Ye et al. Genetic Transformation of Jatropha curcas. (United States Patent 20110247099 A1).

  7. Jian Ye et al. Increasing cotton fiber length by manipulating transcription factor. (United States Patent PCT/SG2012/000139).

  8. Jian Ye et al. Microsomal ω6 Oleate Desaturases. (U.S. patent application PCT/SG2011/000337).

 

近期代表工作1双生病毒抑制植物MYC2 介导的茉莉酸(JA)抗虫代谢途径,同介体昆虫烟粉虱形成互惠共生关系。A.植物MYC2转录因子转录激活抗虫次级代谢物合成; B. 双生病毒抑制植物MYC2介导的抗虫反应; C. 双生病毒同烟粉虱形成依赖于寄主植物的互惠共生关系 (Li et al. Plant Cell 2014)

近期代表工作2双生病毒“劫持”细胞质RNA降解途径抑制植物基因沉默并促进病毒复制。Ye et al. PLoS Pathogens 2015

近期代表工作3高品质新品种 (A)和高产油量新品种(B)的多年生生物能源树木小桐子(Jatropha curcas)

 

 

 

 

 

 

 

 

80%的植物病毒病害由昆虫媒介传播,1100种已知植物病毒中30%由烟粉虱传播。我们主要研究在自然条件下病毒病害发生的多元生物互作体系的贡献及其互作机制,探求病毒病害防治的重要节点,结合利用大数据平台技术,设计农业生产条件下有效的病毒防治策略。

 

 
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