> 病毒感染与肿瘤发生研究组----中国科学院微生物研究所
 
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病毒感染与肿瘤发生研究组
组长:陈吉龙  研究员

研究方向

抗病毒免疫、肿瘤免疫与肿瘤生物学。
研究内容包括以下几方面:抗病毒免疫的信号转导通路与抗病毒的细胞免疫机理;病毒与癌基因诱发肿瘤发生的分子机制;肿瘤发生的信号转导通路。研究一些重要分子(长非编码RNA,小分子GTPase)的作用机理。

 

研究队伍

课题组长:陈吉龙 研究员 博士生导师, 中国科学院"百人计划" 
电子邮件:chenjl@im.ac.cn
通讯地址:北京市朝阳区北辰西路1号院3号,中国科学院微生物研究所
邮政编码:100101

 

实验室成员

陈玉海,硕士,助理研究员
欧阳晶,博士,博士后 

 

研究生

郭桂杰,博士生

杨建岭,博士生

魏海涛,博士生

  松,博士生

  科,博士生

王雪飞,博士生

钱国敏,硕士生

  芳,硕士生

刘莎莎,硕士生

李建宁,硕士生

朱晓梅,联合培养生

张兆圆,联合培养生

陈庆煌,客座研究生

陈志龙,客座研究生


主要履历及经历

1992,北京大学, 获博士学位
1992-1993,中国科学院遗传与发育生物学研究所(原中国科学院发育生物学研究所),助理研究员。
1993-1994,中国科学院发育生物学研究所,副研究员(中国科学院破格提拔)。
1994-1998,美国爱荷华大学(University of Iowa)生物化学系,博士后。
1998-2000,中国科学院发育生物学研究所,副研究员、研究员。研究组负责人,青年科学家创新小组负责人。
2000-2008,美国爱荷华大学(University of Iowa)医学院访问学者, 研究员,助理研究教授。
2008-至今,中国科学院“百人计划”。中国科学院微生物研究所研究员,研究组负责人,博士生导师。

发表论文

I.

Publications in peer-reviewed Journals

[1]

Fang Li, Yuhai Chen, Zhaoyuan Zhang, Jing Ouyang, Yi Wang, Ruoxiang Yan, Shile Huang, George Fu Gao, Guijie Guo and Ji-Long Chen*. Robust expression of vault RNAs induced by influenza A virus plays a critical role in suppression of PKR-mediated innate immunity. Nucleic Acids Research, 2015 ;43(21):10321-10337. (*通讯作者,下同) 

[2]

Ke Chen, Jianling Yang, Jianning Li, Xuefei Wang, Yuhai Chen, Shile Huang, Ji-Long Chen*. eIF4B is a convergent target and critical effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways in Abl transformants. Oncotarget, 2016 ; doi: 10.18632/oncotarget.7164. 

[3]

Jing Ouyang, Jiayue Hu and Ji-Long Chen*. lncRNAs regulate the innate immune response to viral infection. Wiley Interdiscip Rev RNA (WIREs RNA). 2016;7(1):129-143.

[4]

Zhilong Chen, Guifeng Luo, Quanxi Wang, Song Wang, Xiaojuan Chi, Yifan Huang, Haitao Wei, Baocheng Wu, Shile Huang, Ji-Long Chen*. Muscovy duck reovirus infection rapidly activates host innate immune signaling and induces an effective antiviral immune response involving critical interferons. Veterinary Microbiology. 2015; 175(2-4):232-243. 

[5]

Xuefei Wang, Ke Chen, Guijie Guo and Ji-Long Chen*. Noncoding RNAs and their functional involvement in regulation of chronic myeloid leukemia. Brief Funct Genomics, 2015; pii: elv059. 

[6]

Xiancheng Zeng, Song Wang, Xiaojuan Chi, Shi-long Chen, Shile Huang, Qunqun Lin, Baogui Xi, Ji-Long Chen*. Infection of goats with goatpox virus triggers host antiviral defense through activation of innate immune signaling. Research in Veterinary Science. 2016; 104:40-9. (doi: 10.1016/j.rvsc.2015.11.006.) 

[7]

Mohsan Ullah Goraya, Song Wang, Muhammad Munir, Ji-Long Chen*. Induction of innate immunity and its perturbation by influenza viruses. Protein & Cell. 2015; 6(10):712-721. 

[8]

Jing Ouyang, Xiaomei Zhu, Yuhai Chen, Haitao Wei, Qinghuang Chen, Xiaojuan Chi, Baomin Qi, Lianfeng Zhang, Yi Zhao, George Fu Gao, Guoshun Wang, Ji-Long Chen*. NRAV, a Long Noncoding RNA, Modulates Antiviral Responses through Suppression of Interferon-Stimulated Gene Transcription. Cell Host & Microbe, 2014; 16(5):616-626.

[9]

Qinghuang Chen, Ke Chen, Guijie Guo, Fang Li, Chao Chen, Song Wang, Grzegorz Nalepa, Shile Huang, Ji-Long Chen*. A Critical Role of CDKN3 in Bcr-Abl-Mediated Tumorigenesis. PLoS One, 2014; 9(10):e111611

[10]

Guomin Qian, Song Wang, Xiaojuan Chi, Hua Li, Haitao Wei, Xiaomei Zhu, Yuhai Chen, Ji-Long Chen*. The amino-terminal region of the neuraminidase protein from avian H5N1 influenza virus is important for its biosynthetic transport to the host cell surface. The Veterinary Journal, 2014; doi:10.1016/j.tvjl.2014.10.015

[11]

 Haitao Wei, Song Wang, Qinghuang Chen, Yuhai Chen, Xiaojuan Chi, Lianfeng Zhang, Shile Huang, George F. Gao, and Ji-Long Chen*. Suppression of Interferon Lambda Signaling by SOCS-1 Results in Their Excessive Production during Influenza Virus Infection. PLoS Pathogens, 2014; 10(1): e1003845.
 [12]  Guijie Guo, Qingzheng Kang, Xiaomei Zhu, Qinghuang Chen, Xuefei Wang, Yuhai Chen, Jing Ouyang, Lianfeng Zhang, Huo Tan, Runsheng Chen, Shile Huang, and Ji-Long Chen*. A long noncoding RNA critically regulates Bcr-Abl-mediated cellular transformation by acting as a competitive endogenous RNA. Oncogene, 2014; (doi:10.1038/onc.2014.131).
 [13]  Song Wang, Xiaojuan Chi, Haitao Wei, Yuhai Chen, Zhilong Chen, Shile Huang, and Ji-Long Chen*. Influenza A virus-induced degradation of eIF4B contributes to the viral replication by suppressing IFITM3 protein expression. Journal of Virology, 2014; (doi:10.1128/JVI.00126-14).
 [14]  Guijie Guo, Qingzheng Kang, Qinghuang Chen, Zhilong Chen, Jun Wang, Li Tan, and Ji-Long Chen*. High expression of long noncoding RNA H19 is required for efficient tumorigenesis induced by Bcr-Abl oncogene. FEBS Letters, 2014; 588(9): 1780-1786.
 [15]  Rong Zhang, Xiaojuan Chi, Song Wang, Baomin Qi, Xiaoqiang Yu, and Ji-Long Chen*. The Regulation of Autophagy by Influenza A Virus. BioMed Research International, 2014; 2014-498083.

[16]

Jianling Yang, Jun Wang, Ke Chen, Guijie Guo, Ruijiao Xi, Paul B. Rothman, Douglas Whitten, Lianfeng Zhang, Shile Huang, and Ji-Long Chen*. eIF4B Phosphorylation by Pim Kinases Plays a Critical Role in Cellular Transformation by Abl Oncogenes. Cancer Research, 2013; 73(15): 4898-4908. (*Correspondence author,下同).
 [17] Quan-Xin Wang, Jian-Ling Yang, Qiu-Yue Qi, Li Bao, Xiao-Li Yang, Miao-Miao Liu, Pei Huang, Li-Xin Zhang*, Ji-Long Chen*, Lei Cai, and Hong-Wei Liu*. 3-Anhydro-6-hydroxy-ophiobolin A, a new sesterterpene inhibiting the growth of methicillin-resistant Staphylococcus aureus and inducing the cell death by apoptosis on K562, from the phytopathogenic fungus Bipolaris oryzae. Bioorganic & Medicinal Chemistry Letters, 2013; 23(12): 3547-3550.
 [18] Ke Chen, Ying-hui Huang, and Ji-long Chen*. Understanding and targeting cancer stem cells: therapeutic implications and challenges. Acta Pharmacol Sin, 2013; 34(6): 732-740. (*Correspondence author). 
 [19] Xiaojuan Chi, Song Wang, Yifan Huang, Mark Stamnes, and Ji-Long Chen*. Roles of Rho GTPases in Intracellular Transport and Cellular Transformation. Int J Mol Sci, 2013; 14(4): 7089-7108. (*Correspondence author).
 [20] Song Wang, Hua Li, Yuhai Chen, Haitao Wei, George F.Gao. , Hongqiang Liu, Shile Huang, Ji-long Chen*. Transport of influenza A virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42. The Journal of Biological Chemistry,287 (13): 9804-9816,2012. (*Correspondence author).

[21]

Xiaoxue Qiu, Guijie Guo, Ke Chen, Masaki Kashiwada, Brian J. Druker, Paul B. Rothman* and Ji-Long Chen*. A requirement for SOCS-1 and SOCS-3 phosphorylation in Bcr-Abl-induced tumorigenesis. Neoplasia14(6):547-558, 2012. (*Correspondence author).

[22]

Kewei Fan, Yinping Jia, Song Wang, Hua Li, Defeng Wu, Guoshun Wang, Ji-long Chen*. 2012. Role of Itk signaling in the interaction between influenza A virus and T cells. Journal of General Virology, 93: 987-997,2012. (*Correspondence author).

[23]

LIU Xiaoling#, ZHAO Zhendong#, XU Chongfeng, SUN Lei, CHEN Jilong,ZHANG Lianfeng, LIU Wenjun. Cyclophilin A Restricts Influenza A Virus Replication through Degradation of the M1 Protein. PLoS ONE,7(2): e31063. (doi:10.1371/journal.pone.0031063.),2012.

[24]

LIU Xiaoling, ZHAO Zhendong, LI Zheng, XU Chongfeng, SUN Lei, CHEN Jilong, LIU Wenjun.Cyclosporin A Inhibits the Influenza Virus Replication through Cyclophilin A-Dependent and –Independent Pathways.PLoS ONE, 7(5): e37277. doi:10.1371/journal.pone.0037277, 2012.

[25]

Yinghui Huang, Xiaoxue Qiu, Ji-long Chen*. Identification of Cancer Stem Cells: from leukemia to solid cancers. Frontiers in Biology, 5(5):407-416, 2010. (*Correspondence author).

[26]

Guijie Guo, Xiaoxue Qiu, Song Wang, Yuhai Chen, Paul B. Rothman, Zixu Wang, Yaoxing Chen, Guoshun Wang, and Ji-long Chen*. The oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B cell transformation and survival of Pim-deficient cells. Oncogene, 29, 3845–3853, 2010. (*Correspondence author).

[27]

Li Q, Qi J, Zhang W, Vavricka CJ, Shi Y, Wei J, Feng E, Shen J, Chen J, Liu D, He J, Yan J, Liu H, Jiang H, Teng M, Li X, Gao GF. The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site.Nature Struct Mol Biol., 17(10):1266-8, 2010.

[28]

Heidi Hehnly, Weidong Xu, Ji-Long Chen, and Mark Stamnes. Cdc42 regulates microtubule-dependent Golgi positioning. Traffic. 11(8):1067-78, 2010

[29]

Heidi Hehnly, Katrina Longhini, Ji-long Chen, Mark Stamnes. Retrograde Shiga Toxin Trafficking is Regulated by ARHGAP21 and Cdc42. Molecular Biology of the Cell, 20 (20): 4303–4312, 2009.

[30]

Ji-long Chen, Andre Limnander, and Paul B. Rothman. Pim-1 and Pim-2 kinases are required for Pre-B cell transformation by v-Abl oncogene. Blood, 111(3):1677-1685, 2008.

[31]

Ji-long Chen, Raymond V. Fucini, Lynne Lacomis, Hediye Erdjument-Bromage, Paul Tempst, and Mark Stamnes. Coatomer-bound Cdc42 regulates dynein recruitment to COPI vesicles. J. Cell Biol., 169(3): 383-389, 2005.

[32]

D. Xie, Z. X. Wang, Y. L. Dong, J. Cao, J. F. Wang, J. L. Chen and Y. X. Chen. Effects of Monochromatic Light on Immune Response of Broilers. Poultry Science, I87: 1535-1539, 2008.

[33]

Yulan Dong, Yaoxing Chen, Zixu Wang, Jumpei Naito, Ji-long Chen. Role of sympathetic nerves in early embryonic development and immune modulation of uterus in pregnant mice. Auton Neurosci. 131:87-93, 2007.

[34]

Henry Pelish, Jeffrey Peterson, Susana Salvarezza, Enrique Rodríguez-Boulan, Ji-long Chen, Mark Stamnes, Eric Macia, Yan Feng, Matthew Shair, Tomas Kirchhausen. Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro. Nature Chemical Biology, 2(1): 39-46, 2006.

[35]

Ji-long Chen, Weidong Xu, and Mark Stamnes. In vitro reconstitution of ARF-regulated cytoskeletal dynamics on Golgi membranes. Methods in Enzymology, 404: 345-358, 2005.

[36]

Hong Cao, Shaun Weller, James D. Orth, Jing Chen, Bing Huang, Ji-long Chen, Mark Stamnes and Mark A. McNiven. Actin and ARF1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport. Nature Cell Biology, 7(5): 483-492, 2005.

[37] 

Ji-long Chen, Lynne Lacomis, et al. Cytosol-derived proteins are sufficient for Arp2/3 recruitment and ARF-dependent actin polymerization on the Golgi membranes. FEBS Letters, 566: 281-286, 2004.
[38] Ji-long Chen Jatinder P. Ahluwalia and Mark Stamnes. Calcium regulates selective anterograde- and retrograde-transport steps in the cell. J. Biol. Chem., 277 (38): 35682-35687, 2002.
[39] Raymond Fucini, Ji-long Chen, Catherine Sharma, Michael M. Kessels and Mark Stamnes. Golgi vesicle proteins are linked to the assembly of an actin complex defined by mAbp1. Molecular Biology of the Cell. 13: 621-631, 2002.
[40]

Ji-long Chen, Kathryn L. Huisinga, Viering  MM., C-ting Wu and Pamela K. Geyer. Enhancer action in trans is permitted throughout the Drosophila genome. Proc. Natl. Acad. Sci. USA., 99(6): 3723-3728, 2002

[41]

Ji-long Chen*, Shu-hong Guo and Fu-hong Gao. Nuclear matrix in developing rat spermatogenic cells. Molecular Reproduction and Development, 59: 314-321, 2001.

[42] Ji-long Chen*, Jie Liu, Kathryn L. Huisinga, James R. Morris, C-ting Wu and Pamela K. Geyer. Characterization of a new tissue-specific mutation of the yellow gene which supports transvection. In: Xue GX, Holmes R, Hammond GH, Lim HA et al. Ed. Gene Families, World Scientific, pp195-202, 2001.
[43]

Jilong-Chen and Frank J. Longo. Expression and localization of DNA topoisomerase II during rat spermatogenesis. Molecular Reproduction and Developmen, 45: 61-71, 1996.

[44] James R. Morris, Ji-long Chen, C-ting Wu and Pamela K. Geyer. Two modes of transvection: enhancer action in trans and bypass of a chromatin insulator in cis. Proc. Natl. Acad. Sci. USA., 95:10740-10745, 1998
[45]  James R. Morris, Ji-long Chen, C-ting Wu and Pamela K. Geyer. An analysis of transvection of Drosophila melanognster. Genetics, 151:633-651, 1999.
[46] Frank J. Longo, Lori Mathews, Ji-long Chen and Daniel L. Weeks. Changes in nuclear Localization of An3, a RNA helicase, during oogenesis and embryogenesis In Xenopus laevis. Molecular Reproduction and Development, 45: 491-502, 1996.
[47]

Zan-Xian Zhou, Ze-Pei Deng and Ji-long Chen. Characterization of glycoconjugates in the endometrium of the miniature pig during different reproductive periods. J. Reproduction and Fertility, 100: 417-423, 1994.

[48] Otilia Zapata, James Ralston, Carmen Beltran, Ji-long Chen, et al. IP3 receptors in Sea Urchin sperm. Zygote, 5:355-364, 1997.
 Ⅱ Publications in peer-reviewed Journals of China
[49] Jilong Chen*, Jie Liu, Zhiwei Chen, Yuliang Zhang, Shuhong Guo and Zhenhua Jin. Involvement of transcriptional enhancers in the regulation of developmental expression of yellow gene. Science in China Series C, 44(2):170-177, 2001. (*Correspondence author).
[50]  Jilong Chen*, Jie Liu, Yuliang Zhang, Zhiwei Chen. Establishment and application of both FLP and Cre site-specific recombination systems at the same position in the genome. Chinese Science Bulletin, 45: 456-460, 2000.
[51] Ji-long Chen*, Zhiwei Chen, Jie Liu, Yuliang Zhang. Expression and location of an RNA helicase during differentiation of spermatogenic cells. Chinese Scientific and Technological Journal. 1305-1306, 1999.
[52] Ji-long Chen*, Jie Liu, Yuliang Zhang. Molecular analysis of gene transvection by using Drosophila yellow gene model. Devel. Reprod. Biol., 7:43-50, 1998.
[53]

Ji-long Chen and Ping Wang. Core filaments of inner-nuclear skeleton in lymphocyte. Acta Zoologica Sinica. 41:111-113, 1995.

[54]

Ji-long Chen and Ping Wang. Intermediate filament-nuclear lamina-nuclear matrix system in B cells. Acta Zoologica Sinica, 40:344-350, 1994.

[55] Ji-long Chen, Aihua Pan and Ping Wang. The induced transcription of metallothionein gene depends on its attachment to the nuclear matrix in lymphocyte of rat spleen. Chinese Science Bulletin. 38:846-848, 1993.
[56] Ji-long Chen, Yulian Zhang and M.C. Niu. The functions of extraneous bacterial chloramphenicol acetyltransferase gene and its transcribed mRNA in the fertilized goldfish eggs. Chinese Science Bulletin. (In Chinese)39: 2106-2109, 1994.
[57] Ji-long Chen*, Yulian Zhang and Jinxing Lin. Nuclear reconstitution around lambda DNA micro-injected into enucleated eggs of Bufo Gargarizans. J. Basic Science and Engineering. 2: 104-108, 1994.
[58] Ji-long Chen and Ping Wang. State of actin polymerization in B cell lines. Acta Anatomica Sinica. 24:396-400, 1993.
[59]

Ji-long Chen and Ping Wang. Intermediate filament system in B cells of the duck embryos. Acta Scientiarum Naturalium Universitatis Pekinensis. 28: 706-711, 1992.

[60]

Ji-long Chen and Ping Wang. Development of Bursa of Fabricius during Late stages of embryonic life and after hatching. Acta Scientiarum Naturalium Universitatis Pekinensis. 29:641-647, 1993.

[61]

Ji-long Chen and Ping Wang. Studies on cytoskeleton in the lymphocyte. Chinese Journal of Zoology. 29: 53-56, 1994.

[62] Zepei Deng and Ji-Long Chen. Observation of T lymphocyte and its subpopulations in peripheral blood in the miniature pig during different stages of sexual cycle and pregnancy. Acta Veterinavia et Zootechnica Sinica. 23:299-302, 1992.
[63] Ji-long Chen and Ping Wang. Changes in the protein composition of intermediate filament-nuclear lamina-nucleur matrix system during lymphocyte differentiation. Acta Anatomica Sinica. 25: 37-42, 1994.
[64] Aihua Pan, Ji-long Chen et al. Application of monoclonal antibody against rabbit liver metallothionein. Chinese Journal of Microbiology and Immunoldogy. 12: 197-200, 1992.
[65] Ji-long Chen and Ping Wang. Cellular studies on intermediate filament-nuclear lamina-nuclear skeleton system in the lymphocytes from Bursa Fabricius with special reference to lymphocyte differentiation. Acta Anatomica Sinica. 25:43-48, 1994.
[66]  Ji-long Chen and Zepei Deng. A survey of changes about mast cells in the endometrium of miniature pigs. Acta Veterinavia et Zootechnica Sinica. 25: 71-77, 1994.

 

 
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