> 分子病毒与生物制药研究组----中国科学院微生物研究所
 
网站地图 联系我们 English 中国科学院
首页 概况简介 机构设置 人才队伍 研究生/博士后 院地合作 国际交流 科研平台 学术出版物 党建 文化 科学传播 信息公开  
研究体系
微生物资源与大数据中心
微生物资源前期开发国家重点实验室
真菌学国家重点实验室
中国科学院微生物生理与代谢工程重点实验室
植物基因组学国家重点实验室
中国科学院病原微生物与免疫学重点实验室
技术转移转化中心
学术团队
环境微生物与生物技术研究中心
分子病毒研究中心
分子免疫研究中心
结核药物研发中心
您现在的位置:首页 > 机构设置 > 研究体系 > 中国科学院病原微生物与免疫学重点实验室
分子病毒与生物制药研究组
组长:刘文军  研究员

研究方向

病毒与宿主细胞相互作用、动物病毒分子进化以及新型免疫增强剂和抗病毒药物。   

研究队伍 

课题组长 

刘文军研究员,英文名 : Wenjun (Frank) Liu 博士,研究员,博士生导师 

教育经历(按时间倒序排序): 

1991/5 - 1996/5,美国佛罗里达大学,分子和细胞生物学,博士 

1982/8 - 1985/8,北京农业大学,动物组织胚胎学,硕士 

1978/3 - 1982/8,北京农业大学,兽医,学士 

工作简历: 

1985/8-1991/5,北京农业大学实验动物研究所,研究所助理,讲师 

1988/8-1989/8,美国国立动物病研究中心,访问学者 

1996/5-1998/3,美国Oklahoma大学医学中心,博士后 

1998/3 - 2000/1,美国Oklahoma医学研究基金会/哈佛休斯医学研究所,Research Associate 

2000/1 - 2004/8,美国GENZYME公司,Scientist 

2004/10 - 至今,中国科学院微生物研究所 研究员、博士生导师 目前任中国科学院微生物研究所分子病毒及生物制药中关村开放实验室主任、中国科学院病原微生物与免疫学重点实验室副主任、分子病毒中心主任、中国科学院微生物研究所生物安全三级实验室主任 

    

主要研究领域: 

病毒与宿主细胞相互作用、疫苗设计以及新型免疫增强剂和抗病毒药物研发。 

 

主要承担项目: 

承担了国家自然科学基金重点、面上项目,科技部国家重点研发计划,卫生部重大传染病防治专项,中国科学院重点部署项目等。 

    

主要社会兼职情况: 

  1. 中国科学院大学存济医学院 兼职教授 医学病毒学课程首席教授 

  中国农村技术开发中心总体专家组专家-“畜禽重大疫病防控与高效安全养殖综合技术研发专项”专家 

  2. 中国微生物学会  常务理事 

  3. 中国工程学报 编委 

  4. 中国微生物学会微生物生物安全专业委员会主任委员 

  5. 中国科技大学、广西大学、安徽大学兼职教授 

  6. 第一届国家卫生部病原微生物生物安全评价委员会委员 

  7. 第一届中国兽医协会 常务理事 

  8. 中国兽医公共卫生学会 常务理事 

  9. 第二届亚洲突发传染病研究合作组织 理事会主席 

  10. 农业部农产品风险评估专家 

  工作人员 

        博士  副研究员                  Lei Sun   Ph.D., Associate professor 

    杨利敏  博士在读  副研究员              Limin Yang  MS, Associate professor 

    李    博士  副研究员                  Jing Li  Ph.D., Associate professor 

    范文辉  博士  助理研究员                Wenhui Fan  Ph.D., Research Assistant 

    李云龙  研究助理                        Yunlong Li   Research Assistant  

    祝荣格  研究助理                        Rongge Zhu  Research Assistant  

    梁希    研究助理                        Xi Liang     Research Assistant  

    张鹤    研究助理                        He Zhang     Research Assistant  

    魏艳秋  研究助理                        Yanqiu Wei    Research Assistant  

      王  选    研究助理                        Xuan Wang   Research Assistant  

    

  博士研究生  

  崔亮 2014-2016                            Liang/Cui 2014-2016 

  杨文贤 2015-2017                          Wenxian/Yang 2015-2017 

  石金超 2015-2017                          Jinchao/Shi 2015-2017 

  白晓园 2017-2020                          Xiaoyuan/Bai 2017-2020 

  焦鹏涛 2017-2020                          Pengtao/Jiao 2017-2020 

  闵洁 2017-2021                            Jie/Min 2017-2021 

    

  硕士研究生 

  马迪娜·马合苏提汗 2015-2017             Madina/Ma   2015-2017 

  刘丽蓉 2016-2019                         Lirong/Liu   2016-2019 

  王萌 2017-2020                           Meng/Wang  2017-2020 

  田璐 2017-2020                           Lu/Tian  2017-2020 

  田晓东 2017-2020                         Xiaodong/Tian  2017-2020 

  李明慧 2017-2020                         Minghui/Li  2017-2020 

  刘杨 2017-2020                           Yang/Liu  2017-2020 

    

  代表文章(近10年): 

  1. W-J Chai #, J Li#, Q Shangguan, Q Liu, X-D Li, D-D Qi, X-M Tong, W-J Liu, X Ye*. 2018. Lnc-ISG20 inhibits influenza A virus replication by enhancing ISG20 expression. Journal of Virology. doi: doi:10.1128/JVI.00539-18 

  2. J Li, K Zhang, Q-Y Chen, X Zhang, Y-P Sun, Y-H Bi, S Zhang, J-Y Gu, J-R Li, Di Liu, W-J Liu*, J-Y Zhou*. 2018. Three Amino Acid Substitutions in the NS1 Protein change the Virus Replication of H5N1 Influenza Virus in Human Cells. Virology. doi: 10.1016/j.virol.2018.04.004 

  3. Y Li, L Sun*, W-N Zheng, Madina·M, J Li, Y-H Bi, H Wang, W-J Liu*, Luo T*. 2018. Phosphorylation and dephosphorylation of threonine 188 innucleoprotein  is crucial for the replication of influenza A virus. Virology. doi: 10.1016/ j.virol.2018.05.002 

  4. C Chen, W-H Fan, J Li, W-N Zheng, S Zhang, L-Y Yang, D Liu, W-J Liu*, L Sun*. 2018. A Promising IFN-Deficient System to Manufacture IFN-Sensitive Influenza Vaccine Virus. Front. Cell. Infect. Microbiol. 8:127. doi.org/10.3389/fcimb.2018.00127 

  5. Y-P Sun, J-W Jiang, P Tien, W-J Liu*, J Li*. 2018. IFN-λ: A new spotlight in innate immunity against influenza virus infection. Protein & Cell. doi: 10.1007/s13238-017-0503-6 

  6. Y-P Sun, J Li*, P Tien, George Fu Gao, W-J Liu*. 2018. Bunyavirales Ribonucleoproteins: the Viral Replication and Transcription Machinery. Critical Reviews in Microbiology. doi: 10.1080/1040841X.2018.1446901 

  7. J Li, J Lu, S Zhang, Wang J, F Liu, M Fang, X-F Duan*, W-J Liu. 2018. Differential Immune Response of Influenza A Virus-infected Dendritic Cells and Association with Autophagy. Future Virology. 10.2217/fvl-2017-0044. 

  8. W Liu#, J Li#, W-N Zheng, Y-L Shang, Z-D Zhao, S-S Wang, Y-H Bi, S Zhang, C-F Xu, Z-Y Duan, L-F Zhang, Y Wang, Z-F Jiang, W-J Liu*, L Sun*. 2017. Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses. Elife, 6(8); 6. pii: e24425 

  9. J L#i, W-N Zheng#, L-D Hou#, C Chen, W-H Fan, H-R Qu, J-W Jiang, J Liu, George Fu Gao, J-Y Zhou, L Sun*, W-J Liu*. 2016. Differential Nucleocytoplasmic Shuttling of the Nucleoprotein of Influenza A Viruses and Association with Host Tropism. Cellular Microbiology. doi: 10.1111/cmi.12692 

  10.W-N Zheng#, S-S Cao#, C Chen#, J Li, Sh Zhang, J-W Jiang, Y-G Niu, W-H Fan, Y Li, Y-H Bi, George Fu Gao, L Sun*, W-J Liu*. 2016. Threonine 80 phosphorylation of non-structural protein 1 regulates the replication of influenza A virus by reducing the binding affinity with RIG-I. Cellular Microbiology. doi:10.1111/cmi.12643. 

  11. J Li, C Chen, Gary W, W Dong, W-N Zheng, Y Li, L Sun, L-F Zhang, George Fu Gao, Y-H Bi, W-J Liu*. 2016. Cyclophilin A protects mice against infection by influenza A virus. Scientific reports 28978. 

  12. J-W Jiang, J Li*, W-H Fan, W-N Zheng, M Yu, C Chen, L Sun, Y-H Bi, C Ding, George Fu Gao, W-J Liu*. 2016. Robust Lys 63-linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection. Journal of Virology. pii: JVI.00549-16. 

  13. Y-G Niu, Y Liu, L-M Yang, H-R Qu, J Zhao, R-L Hu, J Li*, W-J Liu*. 2016. Evaluation of the immunogenicity of multi-epitope-based vaccine candidates against rabies adjuvant with Gp96. Virologica Sinica, 4; 31(2):168-75. 

  14. J Li, Y-H Rao, Q-L Sun, X-X Wu, J Jin, Y-H Bi, J Chen, F-M Lei, Q-Y Liu, Z-Y Duan, J-C Ma, George Fu Gao, D Liu, W-J Liu*. 2015. Identification of climate factors related to human infection with avian influenza A H7N9 and H5N1 viruses in China. Scientific reports, 18094, doi: 10.1038/srep18094 

  15. J Li, W-J Liu*. 2015. Diversity of the RNA polymerase in the H7N9 Influenza A Virus. Advances in Microbiology, 5: 661-667 

  16.   J Li, T Qin, X-X Jia, A-H Deng, X Zang, W-H Fan, S-D Huo, T-Y Wen, W-J Liu*. 2015. Rapid Identification of Legionella Pathogenicity by Surface-Enhanced Raman Spectroscopy. Biomedical and Environmental Sciences, 2015; 28(6): 77-84 

  17.   X-J Jia, Y-H Bi, J Li, Q Xie, H-C Yang*, W-J Liu*.2015. Cellular microRNA miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by activating innate antiviral immunity, Scientific reports, 10651 

  18.   K Zhang#, Z Wang#, G-Z Fan, J Wang, S-Y Gao, Y Li, L Sun, C-C Yin*, W-J Liu*. 2015. Two Polar Residues Within C-terminal Domain of M1 are Critical for the Formation of Influenza A Virus Matrix Layer, Cellular Microbiology (10)1111/cmi.12457 

  19.   J Li, M Yu, W-N Zheng, W-J Liu*. 2015. Nucleocytoplasmic Shuttling of Influenza A Virus Proteins, Viruses 7, 2668-2682. 

  20.   W-N Zheng, J Li, S-S Wang, S Cao, J-W Jiang, C Chen, C Ding, C Qin, X Ye, George Fu Gao, W-J Liu*. 2015. Phosphorylation controls the nuclear-cytoplasmic shuttling of influenza A virus nucleoprotein. Journal of Virology. 3(18). pii: JVI.00015-15. 

  21.   Y-H Bi, Q Xie, S Zhang, Y Li, H-X Xiao, T Jing, WN Zheng, J Li, X-J Jia, L Sun, J-H Liu, C Qin, George F Gao, W-J Liu*. 2014. Assessment of the internal genes of influenza A (H7N9) virus contributing to the high pathogenicity in mice. Journal of Virology. doi:10.1128/JVI.02390-14 

  22.   Y-H Bi, J Li, L-M Yang, S Zhang, Y Li, X-J Jia, L Sun, Y-B Yin, C Qin, B-N Wang, George Fu Gao, W-J Liu*. 2014. Assessment of the pathogenesis of Streptococcus suis type 2 infection in piglets for understanding streptococcal toxic shock-like syndrome, meningitis, and sequelae. Vet Microbiol, doi:10.1016/j.vetmic.2014.08.010 

  23.   Sh Cao#, J-W Jiang#, J Li, Y Li, L-M Yang, Sh-Sh Wang, J-H Yan, George F Gao, W-J Liu*. 2014. Characterization of The Nucleocytoplasmic Shuttle of The Matrix Protein of Influenza B Virus. Journal of Virology.88 (13):7464-7473 

  24.   Sh-Y Gao, Sh-Sh Wang, Sh Cao, L Sun, J Li, Y-H Bi, George F Gao, W-J Liu*. 2014. The characteristics of nucleocytoplasmic transport of H1N1 influenza A viruses nuclear export protein (NEP). Journal of Virology. 88 (13):7455-7463 

  25.   L Xu, L-M Yang, W-J Liu*.2013. Distinct evolution process among type I interferon in mammals. Protein Cell. May;4(5):383-92 

  26.   S-S Wang, Zh-D Zhao, Y-H Bi, L Sun, X-L Liu*, W-J Liu*.2013. Tyrosine 132 phosphorylation of influenza A virus M1 protein is crucial for virus replication by controlling its nuclear import. Journal of Virology, 87(11):6182-91 

  27.   J Li, Y-H Bi, C Chen, L-M Yang, W-J Liu*. 2013. Genetic characterization of Duck Hepatitis A Viruses isolated in China. Virus Research. (doi:10.1016/j.virusres.2013.10.007) 

  28.   X-L Liu, Zh-D Zhao, W-J Liu*.2013. Insights into the Roles of Cyclophilin A during Influenza Virus Infection. Viruses. 5:182-191 

  29.   L-M Yang, J-Y Cen, Q-H Xue, J Li, Y-H Bi, L Sun, W-J Liu*.2013. Identification of Rabies Virus Mimotopes Screened from a Phage Display Peptide Library with Purified Dog Anti-Rabies Virus Serum IgG.. Virus Research. 174:47-51 

  30.   H-R Qv#, L-M Yang#, S-S Meng, L Xu, Y-H Bi, X-J Jia, J Li, L Sun, W-J Liu*.2013. The Differential Antiviral Activities of Chicken Interferon α (ChIFN-α) and ChIFN-β Are Related to Distinct Interferon-stimulated Gene Expression, PLoS One. (doi: 10.1371/journal.pone.0059307) 

  31.   C-W Chen, J Li, Y-H Bi, L-M Yang, S-S Meng, Y-C Zhou, X-J Jia, S-D Meng, L Sun, W-J Liu*.2013. Synthetic B- and T-cell epitope peptides of porcine reproductive and respiratory syndrome virus with Gp96 as adjuvant induced humoral and cell-mediated immunity, Vaccine. (doi: http://dx.doi.org/10.1016/j.vaccine.2013.01.049) 

  32.   C-W Chen, W-H Fan, X-J Jia, J Li, Y-H Bi, W-J Liu* 2013. Development of a recombinant N-Gp5c fusion protein-based ELISA for detection of antibodies to porcine reproductive and respiratory syndrome virus. J Virol Methods. 4:189(1):213-20 

  33.   Sh Cao, Yi Shi, Sh-G Tan, H Song, George F. Gao*, W-J Liu*. 2012. Reply to "Nuclear Export Signal and Immunodominant CD8+ T Cell Epitope in Influenza A Virus Matrix Protein 1"--Sequence Sharing Between Viral Nuclear Export Signals (NES) and CD8+ T Cell Epitopes. Journal of Virology, 86(18):10259-10260 

  34.   M-R Yu#, X-L Liu#, Sh Cao, Zh-D Zhao, K Zhang, Q Xie, C-W Chen, Sh-Y Gao, Y-H Bi, L Sun, X Ye, George F. Gao, W-J Liu*. 2012. Identification and Characterization of three novel nuclear export signals in influenza A virus nucleoprotein. Journal of Virology, 86(9):4970-80 

  35.   Sh Cao, X-L Liu, M-R Yu, J Li, X-J Jia, Y-H Bi, L Sun, George F. Gao, W-J Liu*. 2012. A Nuclear Export Signal in the Matrix Protein of Influenza A Virus Is Required for the Efficient Virus Replication. Journal of Virology, 86(9):4883-91 

  36.   X-L Liu#, Zh-D Zhao#, Zh Li, Ch-F Xu, L Sun, J-L Chen, W-J Liu* 2012. Cyclosporin A inhibits the Influenza Virus Replication through cyclophilin A-dependent and -independent pathways. PLoS ONE, 7(5):e37277 

  37.   K Zhang, Zh Wang, X-L Liu, Ch-ch Yin, Basit Zeshan, B Xia*, W-J Liu*. 2012. Dissection of Influenza A Virus M1 Protein: pH-Dependent Oligomerization of N-Terminal Domain and Dimerization of C-Terminal Domain. PLoS ONE, 7(5): e37786. 

  38.   X-L Liu#, Zh-D Zhao#, Ch-F Xu, L Sun, J-L Chen, L-F Zhang, W-J Liu*. 2012. Cyclophilin A Restricts Influenza A Virus Replication through Degradation of the M1 Protein. PLoS ONE, 7(2): e31063. 

  39.   C-W Chen, J Li, Y-H Bi, X-J Jia, S-D Meng, L Sun, W-J Liu*. 2012. Gp96 enhances the immunogenicity of subunit 1 vaccine of Porcine reproductive and 2 respiratory syndrome virus. Virus Research, 167(2):162-72. 

  40.   Y-L Wang, J Li, Y-H Bi, L Xu, W-J Liu*. 2012. Development and application of a reverse transcription loop-mediated isothermal amplification method for rapid detection of Duck hepatitis A virus type 1. Virus Genes, doi 10.1007/s11262-012-0798-6 

  41.   Z-F Wang, X-L Liu, Z-D Zhao, C-F Xu, K Zhang, C-W Chen, L Sun, F Gao, X Ye, W-J Liu*, 2011, Cyclophilin E functions as a negative regulator to influenza virus replication by impairing the formation of the ribonucleoprotein complex. PLoS ONE 6(8): e22625. doi:10.1371/journal.pone.0022625 

  42.   S-S Meng, L-M Yang, C-F Xu, Z-M Qin, H-Y Xu, Y-L Wang, L Sun and W-J Liu*. Recombinant Chicken Interferon-α Inhibits H9N2 Avian Influenza Virus Replication in vivo by Oral Administration. Journal of Interferon and Cytokine Research. 2011, 7; 31(7):533-8 

  43.   Y-H Bi#, L Lu#, J Li, Y-B Yin, Y Zhang, H-J Gao, Zh-M Qin, Basit Zeshan, J-H Liu, W-J Liu*, L Sun*. Novel genetic reassortants in H9N2 influenza A Viruses and the diverse pathogenicity to mice. Virology Journal, 2011, 8:505 

  44.   L Lu, Y-B Yin, Z-S Sun, L Gao, F Gao, S-D Liu, L Sun* and W-J Liu*. 2010. Genetic correlation between current circulating H1N1 swine and human influenza viruses. Journal of Clinical Virology. 49(3): 186-91. 

  45.   M-R Yu, X-L Liu, L Sun, C-W Chen, G-P Ma, Y. Kitamura, F Gao and W-J Liu*. 2010. Subcellular localization and topology of porcine reproductive and respiratory syndrome virus E protein. Virus Research. 152(1-2): 104-14. 

  46.   C-F Xu, S-S Meng, X-L Liu, L Sun and W-J Liu*. 2010. Chicken Cyclophilin A is an inhibitory factor to influenza virus replication. Virology Journal. 7(1): 372. 

  47.   Q-H Xue, L-M Yang, X-L Liu and W-J Liu*. 2010. Molecular characterization of feline interferon receptor 2. Journal of Interferon and Cytokine Research. 30(2): 81-8. 

  48.   L Sun, G-H Zhang, Y-L Shu, X-M Chen, Y-P Zhu, L-M Yang, G-P Ma, Y.Kitamura and W-J Liu*. 2009. Genetic correlation between H3N2 human and swine influenza viruses. Journal of Clinical Virology. 44(2): 141-4. 

  49.   X-L Liu, L Sun, M-R Yu, Z-F Wang, C-F Xu, Q-H Xue, K Zhang, X Ye, Y. Kitamura and W-J Liu*. 2009. Cyclophilin A interacts with influenza A virus M1 protein and impairs the early stage of the viral replication. Cellular Microbiology. 11(5): 730-41. 

  50.   J-J Zhang, G Li, X-L Liu, Z-F Wang, W-J Liu* and X Ye*. 2009. Influenza A virus M1 blocks the classical complement pathway through interacting with C1qA. Journal of General Virology. 90(11): 2751-8. 

  51.   D Liu, X-L Liu, J-H Yan, W-J Liu* and F. Gao*. 2009. Interspecies transmission and host restriction of avian H5N1 influenza virus. Science in China Series C: Life Science. 52(5): 428–38. 

    

 

     

 

 

授权国家发明专利: 

序号 

专利名称 

申请号 

发明人 

申请日 

授权日 

1 

利用CRISPR-Cas9系统构建的敲除IFN-β基因的293T细胞系 

201410806018.0 

刘文军,李晶,范文辉,李芸,张爽 

2014.12.22 

2017.08.11 

2 

一种鸭病毒性肝炎的灭活疫苗及其制备方法与应用 

201410834435.6 

刘文军,李晶,张爽,张万林,范国兵 

2014.12.26 

2017.07.28 

3 

一种检测禽流感病毒的表面增强拉曼光谱基底物及其应用 

201410697470.8 

刘文军;李学兵;杨利敏;李晶;贾晓娟;孙蕾;刘志刚 

2014.11.26 

2017.06.30 

4 

用于鉴定军团菌毒力的方法 

201410409558.5 

刘文军,李晶,秦天,任红宇,贾潇潇,周海健,邵祝军,杨利敏 

2014.08.19 

2016.08.17 

5 

ISG20蛋白及其编码基因在抗流感病毒中的应用 

201410258176.7 

刘文军,贾晓娟,瞿洪仁,崔亮,徐磊 

2014.06.11 

2016.05.11 

6 

一种用于预防猪口蹄疫的干扰素白油组合物 

201410141669.2 

刘文军,李晶,杨利敏,李芸,徐磊 

2014.04.10 

2015.09.16 

7 

导入特异shRNA得到的CypA基因被沉默的重组哺乳动物细胞 

201310674488.1 

刘文军,李晶,陈吉龙,杨利敏,赵振东 

2013.12.11 

2015.07.15 

8 

一种猪肺特异性启动子及其应用 

201310447351.2 

刘文军,李晶,毕玉海,贾晓娟,曹帅 

2013.09.25 

2016.01.20 

9 

流感病毒M1蛋白及其编码基因和应用 

201310384342.3 

刘文军,范文辉,李晶,毕玉海,杨利敏,贾晓娟 

2013.08.29 

2016.01.20 

10 

针对鸡新城疫病毒、禽流感病毒和鸡传染性支气管炎病毒的三联卵黄抗体 

201310322565.7 

刘文军,李晶,杨利敏,李云龙,伏显华 

2013.07.29 

2015.06.24 

11 

CypA蛋白片段及其在制备抗炎症药物中的应用 

201210560379.2 

刘文军,李晶,杨利敏,贾晓娟,范文辉,伏显华,岑峻宇,孙蕾 

2012.12.20 

2014.07.16 

12 

鸡源热休克蛋白及其编码基因和应用 

201110062682.5 

刘文军,瞿洪仁,李晶,杨利敏,陈才伟 

2011.03.15 

2014.03.19 

13 

抑制A型流感病毒M1蛋白发生磷酸化的方法及其应用 

201210477870.9 

刘文军,王珊珊,赵振东,刘晓玲,李晶 

2012.11.22 

2014.02.05 

14 

利用毕赤酵母生产猪Gp96蛋白的方法及专用培养基 

201210037467.4 

刘文军,贾晓娟,陈才伟 

2012.02.17 

2014.01.01 

15 

检测I型鸭肝炎病毒的环介导等温扩增试剂盒及应用 

201210143460.0 

刘文军,杨利敏,许磊,毕玉海,李晶,孙蕾 

2012.05.09 

2014.01.01 

16 

一种动物呼吸道特异性启动子及其应用 

201210323711.3 

刘文军,杨利敏,徐磊 

2012.09.04 

2014.01.01 

17 

特异多肽在制备狂犬病疫苗中的应用 

201110306464.1 

刘文军,杨利敏,毕玉海,李晶,孙蕾 

2011.10.11 

2013.08.07 

18 

多肽片段组合物及其在制备猪繁殖与呼吸综合征疫苗中的应用 

201110229827.6 

刘文军,陈才伟,李晶,杨利敏 

2011.08.11 

2013.03.20 

19 

一株鸡源H9N2禽流感病毒毒株及其应用 

201110322027.9 

刘文军,范国兵,毕玉海,李晶,张万林,杨利敏,孙蕾 

2011.10.20 

2013.03.20 

20 

优化的草鱼α干扰素编码基因及其应用 

201010549303.0 

刘文军,杨利敏,范文辉,李晶,秦文安 

2010.11.18 

2012.12.19 

21 

预防鸭病毒性肝炎的灭活疫苗及其制备方法 

201010611929.X 

赵亚荣,刘文军,王贵华,李晶,牟巍 

2010.12.29 

2012.11.21 

22 

辅助鉴定猪链球菌2型与猪链球菌7型的专用引物及其应用 

201110041448.4 

刘文军,毕玉海,李晶 

2011.02.21 

2012.10.10 

23 

预防鸭病毒性肝炎的灭活疫苗及其制备方法 

201010247306.9 

刘文军,王贵华,李晶,赵亚荣,牟巍 

2010.08.06 

2012.08.15 

24 

编码鸡α干扰素的优化基因及其在制备鸡α干扰素中的应用 

201010270554.5 

刘文军,瞿洪仁,李晶,杨利敏,贾晓娟 

2010.09.01 

2012.08.08 

25 

猪用抗原呈递蛋白及其编码基因和应用 

201010140598.6 

刘文军,陈才伟,杨利敏,孙蕾,李晶 

2010.04.02 

2012.02.01 

26 

一种预防猪生殖与呼吸综合征的疫苗 

201010183417.8 

刘文军,陈才伟,孙蕾,李晶 

2010.05.19 

2012.01.04 

27 

一种检测狂犬病病毒的酶联免疫试剂盒 

200610113337.9 

刘文军,杨利敏 

2006.09.22 

2011.05.18 

28 

一种猫α干扰素及其编码基因与其应用 

200610112963.6 

刘文军,杨利敏 

2006.09.13 

2010.11.24 

29 

一种改良重组猪α干扰素蛋白及其编码基因与应用 

200710176867.2 

刘文军,杨利敏,孙蕾 

2007.11.06 

2009.05.06 

30 

γ干扰素及其编码基因与应用 

200710120248.1 

刘文军,杨利敏,孙蕾 

2007.08.14 

2009.01.14 

31 

ω干扰素及其编码基因与应用 

200510089864.6 

刘文军,杨利敏,杨帆 

2005.08.09 

2007.05.02 

 

 

 
1996-2014 中国科学院微生物研究所 版权所有   备案序号:京ICP备05064432号   文保网安备案号:110402500054
地址:北京市朝阳区北辰西路1号院3号  邮编:100101 电话:86-10-64807462 传真:86-10-64807468 Email:office@im.ac.cn