> 病毒复制与细胞周期调控的分子机制----中国科学院微生物研究所
 
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病毒复制与细胞周期调控的分子机制
组长:叶 昕  研究员

研究方向

本课题组主要研究宿主与流感病毒互作及HBV调控细胞周期/凋亡的信号通路的分子机制。 

研究队伍

课题组长:叶 昕  研究员 博士生导师
电子邮件:yex@im.ac.cn

通讯地址:北京市朝阳区北辰西路1号院3号,中国科学院微生物研究所
邮编:100101

组员

童晓梅 助理研究员
刘宁宁 助理研究员
胡  毅 助理研究员

研究生

孙莉萍  2009-2015
黄  艳  2010-2015
焦  童  2011-2016
张廷虹 2012-2015
秦玉洁 2012-2015
柴文佳 2014-2019
刘  琪 2014-2017
叶  榛 2013-2016
杨小海 2014-2017
张  芳 2015-2020
李信达 2015-2018

主要履历及经历

1980-1984  厦门大学学士
1984-1987  中科院上海细胞生物学研究所硕士
1987-1990  中国医学科学院肿瘤研究所博士
1990-1992  中科院上海生物化学研究所
1992-1993  中科院上海生物工程中心副教授
1994-1995  美国洛克菲勒大学博士后
1995-1998  美国哥伦比亚大学博士后
1998-2000  美国伊利诺伊斯大学芝加哥分校博士后
2000-2003  美国贝勒医学院讲师
2003-2005  美国哈佛医学院讲师
2005-至今  中科院微生物所研究员、博士生导师

发表论文

1

Wenjia Chai, Jing Li, Qilin Shangguan, Qi Liu, Xinda Li, Dandan Qi, Xiaomei Tong, Wenjun Liu, Xin Ye. (2018) Lnc-ISG20 inhibits influenza A virus replication by enhancing ISG20 expression. J Virol. doi: 10.1128/JVI.00539-18

2

Ningning Liu, Qi Liu, Xiaohai Yang, Fang Zhang, Xinda Li, Yuanwu Ma, Feifei Guan, Xin Zhao, Zhiwei Li, Lianfeng Zhang, Xin Ye. (2018) Hepatitis B virus-upregulated lnc-HUR1 promotes cell proliferation and tumorigenesis by blocking p53 activity. Hepatology. doi: 10.1002/hep.30098

3

Ningning Liu, Jinfang Zhang , Xiaohai Yang, Tong Jiao, Xin Zhao,Wenxia Li, Jianhua Zhu, Pu Yang, Jianping Jin, Jirun Peng, Zhiwei Li and Xin Ye (2107) HDM2 promotes the NEDDylation of HBV HBx and enhances its stability and functions. J Virol.91, e00340-17

4

Tinghong Zhang, Zhen Ye, Xiaohai Yang, Yujie Qin,Yi Hu, Xiaomei Tong, Wenbin Lai and Xin Ye(2017) NEDDylation of PB2 Reduces Its Stability and Blocks the Replication of Influenza A Virus. Sci Rep. 7: 43691.

5

Yi Hu, Liangzhen Jiang, Wenbin Lai, Yujie Qing, Tinghong Zhang, Shixiong Wang and Xin Ye (2016) MiR-33a disturbs influenza A virus replication via targeting ARCN1 and inhibiting viral vRNP activity. J Gen Virol. 97(1):27-38

6

Yan Huang, Liping Sun, Ningning Liu, Qian Wei, Liangzhen JiangXiaomei Tong and Xin Ye (2015) Polo-like Kinase 1 (Plk1) Up-regulates Telomerase Activity by Affecting Human Telomerase Reverse Transcriptase (hTERT) Stability. J Biol Chem. 290:18865-73 

7

Liping Sun, Yan Huang, Qian Wei, Xiaomei Tong, Rong Cai, Grzegorz Nalepa, Xin Ye. (2015) Cyclin E-CDK2 Protein Phosphorylates Plant Homeodomain Finger Protein 8 (PHF8) and Regulates Its Function in the Cell Cycle. J Biol Chem. 290, 4075-4085.  

8

Ningning Liu, Tong Jiao, Yan Huang, Wenjun Liu, Zhiwei Li, Xin Ye. (2015) Hepatitis B Virus Regulates Apoptosis and Tumorigenesis through the MicroRNA-15a-Smad7- Transforming Growth Factor Beta PathwayJ Virol 89, 2739-2749  

9

Yetao Wang, Lei Hu, Xiaomei Tong and  Xin Ye. 2014. Casein Kinase 1γ1 Inhibits the RIG-I/TLR Signaling Pathway through Phosphorylating p65 and Promoting Its Degradation.  J Immunol. 192:1855-61  

10

 Ningning Liu, Jinfang Zhang, Tong Jiao, Zhiwei Li, Jirun Peng, Qingqing, Cuizhu and Xin Ye. (2013) Hepatitis B virus inhibits apoptosis of hepatoma cells by sponging miR-15a/16 cluster. J Virol. 87(24):13370-78.  

11

Zhaoyang Du, Xiaomei Tong and Xin Ye. (2013) Cyclin D1 Promotes Cell Cycle Progression through Enhancing NDR1/2 Kinase Activity Independent of Cyclin-dependent Kinase 4. J Biol. Chem. 288(37):26678-87. 

12

Qian Wei, Junhui Li, Ting Liu, Xiaomei Tong, Xin Ye. (2013) Phosphorylation of minichromosome maintenance protein 7 (MCM7) by cyclin/cyclin-dependent kinase affects its function in cell cycle regulation. J Biol Chem 288: 19715–19725. 

13

 Liangzhen Jiang, Yan Huang, Min Deng, Ting Liu, Wenbin Lai, Xin Ye. (2013) Polo-Like Kinase 1 Inhibits the Activity of Positive Transcription Elongation Factor of RNA Pol II b (P-TEFb). PLoS ONE 8(8):e72289.  

14

Yetao Wang, Xiaomei Tong and Xin Ye. (2012) Ndfip1 Negatively Regulates RIG-I–Dependent Immune Signaling by Enhancing E3 Ligase Smurf1-Mediated MAVS Degradation. J Immunol. 189:5304-5313. 

15

 Yetao Wang, Xiaomei Tong, Ehimwenma Sheena Omoregie, Wenjun Liu, Songdong Meng, Xin Ye. (2012) Tetraspanin 6 (TSPAN6) Negatively Regulates RIG-I-like Receptors (RLRs) Mediated Immune Signaling in a Ubiquitination Dependent Manner. J Biol. Chem. 287: 34626–34634.. 

 16

Yetao Wang, Xiaomei Tong, Gang Li, Junhui Li, Min Deng and Xin Ye. (2012) Ankrd17 positively regulates RIG-I-like receptor (RLR)-mediated immune signaling. Euro. J Immunol. 42: 1304–1315 

 17

 Yetao Wang, Xiaomei Tong, Junjie Zhang and Xin Ye. (2012) The complement C1qA enhances RIG-I mediated immune signaling. Immunol. 136:78-85.

 18

Junjie Zhang, Ting Liu, Xiaomei Tong, Gang Li, Jinghua Yan and Xin Ye. (2011) Identification of novel virus inhibitors by influenza A virus specific reporter cell based screening. Antiviral Res.93:48-54 

19

 Ting Liu, Min Deng, Junhui Li, Xiaomei Tong, Qian Wei and Xin Ye. (2011) Phosphorylation of Right Open Reading Frame 2 (Rio2) Protein Kinase by Polo-like Kinase 1 Regulates Mitotic Progression. J Biol. Chem. 286: 36352-36360

 20

 Junhui Li, Min Deng, Qian Wei, Ting Liu, Xiaomei Tong and Xin Ye. (2011) Phosphorylation of MCM3 Protein by Cyclin E/Cyclin- dependent Kinase 2 (Cdk2) Protein Regulates Its Function in Cell Cycle. J Biol. Chem. 286:39776-85

21

 Junjie Zhang, Gang Li and Xin Ye. (2010) Cyclin T1/CDK9 Interacts with Influenza A Virus Polymerase and Facilitates Its Association with Cellular RNA Polymerase II. J Virol. 84(24):12619-12627

 22

 Gang Li, Junjie Zhang, Xiaomei Tong, Wenjun Liu and Xin Ye. (2010) Heat shock protein 70 inhibits the activity of influenza a virus ribonucleoprotein and blocks the replication of virus in vitro and in vivo. PLoS ONE 6 (2): e16546

23

 Min Deng, Fahui Li, Bryan A Ballif, Shan Li, Xi Chen, Lin Guo and Xin Ye. (2009Identification and functional analysis of a novel cyclin E/CDK2 substrate Ankrd17. J Biol. Chem. 284:7875-7888. 

24

Junjie Zhang, Gang Li, Xiaoling Liu, Zengfu Wang, Wenjun Liu, and Xin Ye. (2009), Influenza A virus M1 blocks the classical complement pathway through interacting with C1qA. J Gen. Virol. 90:2751-2758 

25

Yali ChenHuijuan GuoZhaoyang Du Xingzhong  LiuYongsheng Che and Xin Ye. (2009) Ecology-based screen identifies new metabolites from a Cordyceps-colonizing fungus as cancer cell proliferation inhibitors and apoptosis inducers. Cell Prolif. 42:838-847. 

26

Xin YeGrzegorz Nalepa, Markus Welcker, Benedikt M. KesslerEric SpoonerJun Qin, Stephen J. ElledgeBruce E. Clurman and J. Wade Harper (2004) Recognition of phosphodegron motifs in human cyclin E by the SCFFbw7 ubiquitin ligase. J. Biol. Chem. 279: 50110-50119. 

27

Xin Ye, Yue Wei, Grzegorz Nalepa, and J. Wade Harper (2003) The cyclin E/Cdk2 substrate p220NPAT is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cells.  Mol. Cell. Biol.  23: 8586-8600. 

28

Deanna M. Koepp, Laura K. Schaefer*Xin Ye*, Khandan Keyomarsi, Claire Chu, J. Wade Harper and Stephen J. Elledge (2001) Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science 294: 173-177. (*, co-second authorship) 

29

Andrei L Gartel, Xin Ye, Eugene Goufman, Pavel Shianov, Nissim Hay, Feridoon Najmabadi and Angela L Tyner (2001) Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3. Proc. Natl. Acad. Sci. USA 98:4510-4515. 

30

Xin Ye, Cihui Zhu, and Wade J Harper (2001) A premature termination mutation in the M. musculus cyclin-dependent kinase 3 (CDK3) gene. Proc. Natl. Acad. Sci. USA  98: 1682-1686. 

31

Changlin Dou *, Xin Ye *, Stewart C, Eseng Lai, and Susanne Li (1997) TWH regulates the development of subsets of spinal cord neurons. Neuron 18: 539-551 (*co-first author). 

 

 
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