研究方向包括细菌功能基因组学与细胞信号感知、病原细菌致病机制和细菌外膜囊泡在毒力调控和疫苗递送中的作用。在细菌识别群体感应信号、金属离子、c-di-GMP胞内信号、寄主激素信号及宿主与环境信号的生物化学机制研究领域做出了突出成果。

1.Wang, Y #; Wang, KM #; Zhang, X; Wang, WZ; Qian, W *; Wang, FF *. 2024. Stenotrophomonas maltophilia uses a c-di-GMP module to sense the mammalian body temperature during infection. PLoS Pathogens. 20(9): e1012533.

2.Qian, W * . 2023. Effector translocation in soil beneficial bacteria, Phytopathology Research. 5(46)

3.Tian, XQ; Wu, Y; Cai, Z; Qian, W *. 2022. BDSF Is a Degradation-Prone Quorum-Sensing Signal Detected by the Histidine Kinase RpfC of Xanthomonas campestris pv. campestris. Applied and Environmental Microbiology. 88(8): e0003122.

4.Yin, X; Qian, W *. 2022. Sword in the woods: How plant hosts defend against vascular pathogens, Journal of Integrative Plant Biology. 64(8): 1465-1468.

5.Ren, BZ; Qian, W *. 2020. Signal perception during plant-bacteria interactions: from chemicals to physical signals. Science China Life Sciences. 63(2): 305-307.

6.Cheng, ST; Wang, FF; Qian, W *. 2019. Cyclic-di-GMP binds to histidine kinase RavS to control RavS-RavR phosphotransfer and regulates the bacterial lifestyle transition between virulence and swimming PLoS Pathogens. 15(8): e1007952.

7.Deng CY#, Zhang H#, Wu Y, Ding LL, Pan Y, Sun ST, Wu Y, Li YJ, Wang L, Qian W *. 2018. Proteolysis of histidine kinase VgrS inhibits its autophosphorylation and promotes osmostress resistance in Xanthomonas campestris. Nature Communications. 9:4791

8.Yang RL#, Deng CY#, Wei JW, He W, Li AN, Qian W *.  2018. A large-scale mutational analysis of two-component signaling system of Lonsdalea quercina revealed that KdpD-KdpE regulates bacterial virulence against host poplar trees. Molecular Plant-Microbe Interactions. 31:724-736.

9.Pan Y, Liang F, Li RJ, Qian W *. 2018. MarR-family transcription factor HpaR controls expression of the vgrR-vgrS operon of Xanthomonas campestris pv. campestris. Molecular Plant-Microbe Interactions. 31:299-310.

10.Wang FF, Cheng ST, Wu Y, Ren BZ, Qian W *. 2017. A bacterial receptor PcrK senses the plant hormone cytokinin to promote adaptation to oxidative stress. Cell Reports. 21:2940-2951.

11.Cai Z#, Yuan ZH#, Zhang H, Pan Y, Wu Yao, Tian XQ, Wang FF, Wang L, Qian W *. 2017. Fatty acid DSF binds and allosterically activates histidine kinase RpfC of phytopathogenic bacterium Xanthomonas campestris pv. campestris to regulate quorum-sensing and virulence. PLoS Pathogens. 13:e1006304.

12.Peng BY#, Pan Y#, Li RJ#, Wei JW, Liang F, Wang L, Wang FF, Qian W *. 2017. An essential regulatory system originating from polygenic transcriptional rewiring of PhoP-PhoQ of Xanthomonas campestris. Genetics. 206:2207-2223.

13.Qian W, Chen XY, Fang RX, Kang L. 2017. Manipulation of biotic signaling: a new theory for smarter pest control. Science China Life Sciences.60:10.1007/s11427-017-9148-x.

14.Wang L, Pan Y, Yuan ZH, Zhang H, Peng BY, Wang FF, Qian W *. 2016. Two-component signaling system VgrRS directly senses extracytoplasmic and intracellular iron to control bacterial adaptation under iron depleted stress. PLoS Pathogens. 12(12):e1006133.

15.Wang FF, Deng CY, Cai Z, Wang T, Wang L, Wang XZ, Chen XY, Fang RX, Qian W *. 2014. A three-component signaling system finetunes expression kinetics of HPPK responsible for folate synthesis by positive feedback loop during stress response of Xanthomonas campestris. Environmental Microbiology, 16:2126-2144.

16.Deng CY, Deng AH, Sun ST, Wang L, Wu J, Wu Y, Chen XY, Fang RX, Wen TY, Qian W *. 2014. The periplasmic PDZ domain-containing protein Prc modulates full virulence, envelop stress responses and directly interacts with dipeptidyl peptidase of Xanthomonas oryzae pv. oryzae. Molecular Plant-Microbe Interactions. 27:101-112.

17.Wang L, Wang FF, Qian W *. 2011. Evolutionary rewiring and reprogramming of bacterial transcription regulation. Journal of Genetics and Genomics. 38:279-288. (Invited review)

18.Wang FF, Wang L, Qian W *. 2010. Two-component signal transduction systems and regulation of virulence factors in Xanthomonas: A perspective. Frontiers in Biology. 5:495-506. (Invited review)

19.Zhang FJ, Guo HY, Zheng HJ, Zhou T, Zhou YJ, Wang SY, Fang RX, Qian W *, Chen XY. 2010. Massively parallel yrosequencing-based transcriptome analyses of small brown planthopper (Laodelphax striatellus), a vector insect transmitting rice stripe virus (RSV). BMC Genomics. 11:303.

20.Qian W#, Jia YT#, Ren SX#, He YQ#, Feng JX#, Lu LF#, Sun QH, Ying G, Tang DJ, Wu W, Hao P, Wang LF, Jiang BL, Zeng SY, Gu WY, Lu G, Rong L, Tian YC, Yao ZJ, Fu G, Chen BS, Fang RX. Qiang BQ, Chen Z, Zhao GP, Tang JL, He CZ. 2005. Comparative and Functional Genomic Analyses of the Pathogenicity of Phytopathogen Xanthomonas campestris pv. campestris. Genome Research. 2005，15: 757-767.

1.中国科学院前瞻战略科技先导专项（A类）“优质甘蔗新品种培育”，2023/10-2028/10；

2.中国科学院前瞻战略科技先导专项（B类）“作物病虫害的导向性防控一生物间信息流与行为操纵”，2014/07-2019/06；

3.国家重点研发计划重点专项“高通量培养筛选鉴定健康相关微生物的关键技术”